Effect of divalent cations on antiparallel G-quartet structure of d(G4T4C4)

被引：89

作者：

Miyoshi, D

Nakao, A

Toda, T

Sugimoto, N

机构：

[1] Konan Univ, Fac Sci & Engn, Dept Chem, Higashinada Ku, Kobe, Hyogo 6588501, Japan

[2] Konan Univ, High Technol Res Ctr, Higashinada Ku, Kobe, Hyogo 6588501, Japan

来源：

FEBS LETTERS | 2001年 / 496卷 / 2-3期

基金：

日本学术振兴会;

关键词：

G-quartet; divalent cation; structural transition; nucleic acid; telomere;

D O I：

10.1016/S0014-5793(01)02416-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The thermodynamic parameters of an antiparallel G-quartet formation of d(G(4)T(4)G(4)) with 1 mM divalent cation (Mg2+, Ca2+, Mn2+, Co2+, and Zn2+) were obtained. The thermodynamic parameters showed that the divalent cation destabilizes the antiparallel G-quartet of d(G(4)T(4)G(4)) in the Following order: Zn2+ > Co2+ > Mn2+ > Mg2+ > Ca2+. In addition, a higher concentration of a divalent cation induced a transition from an antiparattel to a parallel G-quartet structure. These results indicate that these divalent cations are a good tool for regulating the G-quartet structures. (C) 2001 Published by Elsevier Science B.V. on behalf of the Federation of European Biochemical Societies.

引用

页码：128 / 133

页数：6

共 32 条

[1] THE INFLUENCE OF LI+, NA+, MG-2+, CA-2+, AND ZN-2+ IONS ON THE HYDROGEN-BONDS OF THE WATSON-CRICK BASE-PAIRS [J].