Novel stereoselective syntheses of highly functionalized benzannulated pyrrolizidines and indolizidines by samarium diiodide induced cyclizations of indole derivatives

被引：67

作者：

Gross, S ^{[1
]}

Reissig, HU ^{[1
]}

机构：

[1] Free Univ Berlin, Inst Chem Organ Chem, D-14195 Berlin, Germany

来源：

ORGANIC LETTERS | 2003年 / 5卷 / 23期

关键词：

D O I：

10.1021/ol0355581

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Suitably substituted heteroaromatic compounds such as indole and pyrrole derivatives are excellent acceptor units for intramolecular couplings of samarium ketyls. They furnish highly functionalized indole derivatives with very good diastereoselectivities additionally. Intermediate samarium enolates can be trapped by electrophiles, allowing efficient tandem reactions.

引用

页码：4305 / 4307

页数：3

共 33 条

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