The effect of handling techniques on electrostatic charge on spacer devices: A correlation with in vitro particle size analysis

It has been suggested that the output of drugs from large volume spacer devices is affected by the static charge retained within the device. This study correlated the static voltage measured on large volume spacer devices with the particle size distribution of a bronchodilator. The effect of five handling techniques on this relationship was studied; an inverse relationship between respirable fraction (RF) and static voltage was confirmed. Elimination of static in the local environment, and pre-washing in soapy water resulted in the highest RFs. Reducing static on spacers should maximise drug delivery to patients and may result in improved drug efficacy.