Latent-TGF-β:: An overview

被引:100
作者
Lawrence, DA [1 ]
机构
[1] CEA, INRA Radiobiol & Etud Genome, Lab Mixte, F-78352 Jouy En Josas, France
关键词
transforming growth factor-beta (TGF-beta); latent TGF-beta; activation; plasmin; thrombospondin; acidic microenvironments; cancer; fibrosis; atherosclerosis;
D O I
10.1023/A:1010819716023
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The latency associated with the transforming growth factor-betas (TGF-betas) was discovered in 1984. Since the two publications on this subject in that year, there has been on average over sixty reports in which latency was the dominant theme for each of the past 10 years, proof enough of the interest in this field of growth factor research. As the mature 25 kD forms of the TGF-betas are required for them to exert their many, diverse biological effects, it was inevitable that an explanation of the structure and of the activation of the latent complexes be sought. This overview provides a description of these essential points. Now that it has been clearly shown that dysregulation of particular components of the TGF-beta signalling pathway is implicated in many human diseases, the activation of the latent TGF-beta complexes has taken on added importance. Technical improvements enable the distinction of active and latent TGF-beta proteins in vivo and have started to reveal anomalies in the control of activation in relation to various pathological situations.
引用
收藏
页码:163 / 170
页数:8
相关论文
共 104 条
  • [1] Accelerated Publication -: Activation of platelet-transforming growth factor β-1 in the absence of thrombospondin-1
    Abdelouahed, M
    Ludlow, A
    Brunner, G
    Lawler, J
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (24) : 17933 - 17936
  • [2] Abe M, 1998, J CELL PHYSIOL, V174, P186, DOI 10.1002/(SICI)1097-4652(199802)174:2<186::AID-JCP6>3.0.CO
  • [3] 2-K
  • [4] A TRANSFORMING GROWTH-FACTOR-BETA-2 (TGF-BETA-2)-LIKE IMMUNOSUPPRESSIVE FACTOR IN AMNIOTIC-FLUID AND LOCALIZATION OF TGF-BETA-2 MESSENGER-RNA IN THE PREGNANT UTERUS
    ALTMAN, DJ
    SCHNEIDER, SL
    THOMPSON, DA
    CHENG, HL
    TOMASI, TB
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1990, 172 (05) : 1391 - 1401
  • [5] TGF-β1, regulation of Alzheimer amyloid precursor protein mRNA expression in a normal human astrocyte cell line:: mRNA stabilization
    Amara, FM
    Junaid, A
    Clough, RR
    Liang, BH
    [J]. MOLECULAR BRAIN RESEARCH, 1999, 71 (01): : 42 - 49
  • [6] AN ACTIVATED FORM OF TRANSFORMING GROWTH FACTOR-BETA IS PRODUCED BY COCULTURES OF ENDOTHELIAL-CELLS AND PERICYTES
    ANTONELLIORLIDGE, A
    SAUNDERS, KB
    SMITH, SR
    DAMORE, PA
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (12) : 4544 - 4548
  • [7] Analysis of small latent transforming growth factor-beta complex formation and dissociation by surface plasmon resonance - Absence of direct interaction with thrombospondins
    Bailly, S
    Brand, C
    Chambaz, EM
    Feige, JJ
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (26) : 16329 - 16334
  • [8] BARCELLOSHOFF MH, 1993, CANCER RES, V53, P3880
  • [9] THE CELL BIOLOGY OF TRANSFORMING GROWTH-FACTOR-BETA
    BARNARD, JA
    LYONS, RM
    MOSES, HL
    [J]. BIOCHIMICA ET BIOPHYSICA ACTA, 1990, 1032 (01) : 79 - 87
  • [10] BARRETT AJ, 1981, METHOD ENZYMOL, V80, P737