New indole alkaloids from Sarcocephalus latifolius

被引：52

作者：

Abreu, P

Pereira, A

机构：

[1] Univ Nova Lisboa, FCT, CQFB, Dept Quim, P-2825114 Caparica, Portugal

[2] Univ Evora, Dept Quim, Evora, Portugal

来源：

NATURAL PRODUCT LETTERS | 2001年 / 15卷 / 01期

关键词：

Sarcocephalus latifolius; Rubiaceae roots; indole alkaloids; 21-O-methylstrictosamide aglycone; 21-O-ethylstrictosamide aglycone; strictosamide; Plasmodium falciparum;

D O I：

10.1080/10575630108041256

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Phytochemical investigation of the root extract of Sarcocephalus latifolius has led to the isolation of the new indole alkaloids 21-O-methylstrictosamide aglycone and 21-O-ethylstrictosamide aglycone, together with strictosamide, angustine, nauclefine, angustidine, angustoline, 19-O-ethylangustoline, naucleidinal, 19-epi-naucleidinal, quinovic acid-3 beta -O-beta -D-fucopyranoside, quinovic acid-3 beta -O-alpha -L-rhamnopyranoside, scopoletin, and beta -sitosterol. Strictosamide displayed moderate antiplasmodial activity against Plasmodium falciparum.

引用

页码：43 / 48

页数：6

共 12 条

[1] A new indole alkaloid from Sarcocephalus latifolius [J].