Nitrous oxide reverses the increase in striatal dopamine release produced by N-methyl-D-aspartate infusion in the substantia nigra pars compacta in rats

被引：19

作者：

Balon, N

Dupenloup, L

Blanc, F

Weiss, M

Rostain, JC

机构：

[1] IFR Jean Roche, Fac Med Nord, IMNSSA, Lab Physiopathol & Act Therapeut Gaz Press, F-13916 Marseille 20, France

[2] Univ Mediterranee, F-13916 Marseille 20, France

来源：

NEUROSCIENCE LETTERS | 2003年 / 343卷 / 02期

关键词：

basal ganglia; narcosis; rat; voltammetry;

D O I：

10.1016/S0304-3940(03)00340-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Bilateral administration of NMDA (5 X 10(-10) mol) in the substantia nigra pars compacta increases the striatal dopamine (DA) release. However, this enhancing effect of NMDA was suppressed by nitrous oxide exposure at 0.1 MPa, which induced per se a decrease of the DA release. These results show that nitrous oxide exerts a reversal effect on the increase in striatal DA release produced by NMDA receptor activation in the substantia nigra pars compacta. This observation may be related to the fact that nitrous oxide is thought to produce its effects by acting as an NMDA receptor antagonist. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：147 / 149

页数：3

共 17 条

[1] Sigmoidal compression rate-dependence of inert gas narcotic potency in rats: implication for lipid vs. protein theories of inert gas action in the central nervous system [J].

Abraini, JH ;

Rostain, JC ;

Kriem, B .

BRAIN RESEARCH, 1998, 808 (02) :300-304

[2] Immunohistochemical localization of N-methyl-D-aspartate and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptor subunits in the substantia nigra pars compacta of the rat [J].

Albers, DS ;

Weiss, SW ;

Iadarola, MJ ;

Standaert, DG .

NEUROSCIENCE, 1999, 89 (01) :209-220

[3] Opposing effects of narcotic gases and pressure on the striatal dopamine release in rats [J].

Balon, N ;

Kriem, B ;

Dousset, E ;

Weiss, M ;

Rostain, JC .

BRAIN RESEARCH, 2002, 947 (02) :218-224

[4] EVIDENCE FOR N-METHYL-D-ASPARTATE AND AMPA SUBTYPES OF THE GLUTAMATE-RECEPTOR ON SUBSTANTIA-NIGRA DOPAMINE NEURONS - POSSIBLE PREFERENTIAL ROLE FOR N-METHYL-D-ASPARTATE RECEPTORS [J].

CHRISTOFFERSEN, CL ;

MELTZER, LT .

NEUROSCIENCE, 1995, 67 (02) :373-381

[5] INVITRO AND INVIVO CHARACTERIZATION OF THE PROPERTIES OF A MULTIFIBER CARBON ELECTRODE ALLOWING LONG-TERM ELECTROCHEMICAL DETECTION OF DOPAMINE IN FREELY MOVING ANIMALS [J].

ELGANOUNI, S ;

FORNI, C ;

NIEOULLON, A .

BRAIN RESEARCH, 1987, 404 (1-2) :239-256

[6] The role of the NMDA synapse in general anesthesia [J].

Flohr, H ;

Glade, U ;

Motzko, D .

TOXICOLOGY LETTERS, 1998, 101 :23-29

[7] ELECTROCHEMICAL DETECTION OF DOPAMINE RELEASE IN THE STRIATUM OF FREELY MOVING HAMSTERS [J].

FORNI, C ;

NIEOULLON, A .

BRAIN RESEARCH, 1984, 297 (01) :11-20

[8] REALIZATION OF A NEW MULTI-FIBER ELECTROCHEMICAL DEVICE ALLOWING CONTINUOUS INVIVO MEASUREMENTS OF NEUROMEDIATORS [J].

FORNI, C .

JOURNAL OF NEUROSCIENCE METHODS, 1982, 5 (1-2) :167-171

[9]

Gerfen CR, 1996, Handbook of Chemical Neuroanatomy, P371, DOI [10.1016/S0924-8196(96)80004-2, DOI 10.1016/S0924-8196(96)80004-2]

[10] CATECHOLAMINE MECHANISMS IN THE STIMULATION OF MOUSE LOCOMOTOR-ACTIVITY BY NITROUS-OXIDE AND MORPHINE [J].

HYNES, MD ;

BERKOWITZ, BA .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1983, 90 (01) :109-114

← 1 2 →