Ftm is a novel basal body protein of cilia involved in Shh signalling

被引:158
作者
Vierkotten, Jeanette
Dildrop, Renate
Peters, Thomas
Wang, Baolin
Ruether, Ulrich
机构
[1] Univ Dusseldorf, Inst Entwicklungs & Mol Biol Tiere, D-40225 Dusseldorf, Germany
[2] Cornell Univ, Weill Med Coll, Dept Med Genet, New York, NY 10021 USA
来源
DEVELOPMENT | 2007年 / 134卷 / 14期
关键词
basal body; left-right asymmetry; limb development; mouse mutant; neural tube;
D O I
10.1242/dev.003715
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
In this study we show in mice that Ftm ( Rpgrip1l) is located at the ciliary basal body. Our data reveal that Ftm is necessary for developmental processes such as the establishment of left-right asymmetry and patterning of the neural tube and the limbs. The loss of Ftm affects the ratio of Gli3 activator to Gli3 repressor, suggesting an involvement of Ftm in Shh signalling. As Ftm is not essential for cilia assembly but for full Shh response, Ftm can be considered as a novel component for cilium-related Hh signalling. Furthermore, the absence of Ftm in arthropods underlines the divergence between vertebrate and Drosophila Hh pathways.
引用
收藏
页码:2569 / 2577
页数:9
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