Electron microscopic localization of Nogo-A at the postsynaptic active zone of the rat

被引：27

作者：

Liu, YY ^{[1
]}

Jin, WL ^{[1
]}

Liu, HL ^{[1
]}

Ju, G ^{[1
]}

机构：

[1] Fourth Mil Med Univ, Inst Neurosci, Xian 710032, Peoples R China

来源：

NEUROSCIENCE LETTERS | 2003年 / 346卷 / 03期

关键词：

Nogo-A; postsynaptic active zone; immunoreactivity; electron microscope; spinal cord; rat;

D O I：

10.1016/S0304-3940(03)00508-1

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Our previous study has demonstrated intraneuronal localization of Nogo-A in motoneurons of the adult rat spinal cord. In the present study, we wished to explore Nogo-A immunoreactivity at synapses using pre-embedding and post-embedding immunogold cytochemistry. Immuno-old particles for Nogo-A could be identified in dendrites of the spinal cord motoneurons. Some Nogo-A immunogold particles were found in close apposition to the postsynaptic density and the postsynaptic dense bodies at both symmetric and asymmetric synapses. The present finding of Nogo-A at the postsynaptic active zone provides a morphological basis for the possibility that the Nogo-A-Nogo receptor system may contribute to structural plasticity at synapses as well as along the axonal pathway. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：153 / 156

页数：4

共 21 条

[1]

Bareyre FM, 2002, J NEUROSCI, V22, P7097

[2]

Brösamle C, 2000, J NEUROSCI, V20, P8061

[3]

Buffo A, 2000, J NEUROSCI, V20, P2275

[4] Nogo-A is a myelin-associated neurite outgrowth inhibitor and an antigen for monoclonal antibody IN-1 [J].

Chen, MS ;

Huber, AB ;

van der Haar, ME ;

Frank, M ;

Schnell, L ;

Spillmann, AA ;

Christ, F ;

Schwab, ME .

NATURE, 2000, 403 (6768) :434-439

[5]

Fournier AE, 2002, J NEUROSCI, V22, P8876

[6] Identification of a receptor mediating Nogo-66 inhibition of axonal regeneration [J].

Fournier, AE ;

GrandPre, T ;

Strittmatter, SM .

NATURE, 2001, 409 (6818) :341-346

[7] Identification of the Nogo inhibitor of axon regeneration as a Reticulon protein [J].

GrandPré, T ;

Nakamura, F ;

Vartanian, T ;

Strittmatter, SM .

NATURE, 2000, 403 (6768) :439-444

[8]

Huber AB, 2002, J NEUROSCI, V22, P3553

[9] Nogo receptor mRNA expression in intact and regenerating CNS neurons [J].

Hunt, D ;

Mason, MRJ ;

Campbell, G ;

Coffin, R ;

Anderson, PN .

MOLECULAR AND CELLULAR NEUROSCIENCE, 2002, 20 (04) :537-552

[10] Intraneuronal localization of Nogo-A in the rat [J].

Jin, WL ;

Liu, YY ;

Liu, HL ;

Yang, H ;

Wang, Y ;

Jiao, XY ;

Ju, G .

JOURNAL OF COMPARATIVE NEUROLOGY, 2003, 458 (01) :1-10

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