Macrophage polarization and insulin resistance:: PPARγ in control

被引：103

作者：

Charo, Israel F. ^{[1
]}

机构：

[1] Univ Calif San Francisco, Gladstone Inst Cardiovasc Dis, Cardiovasc Res Inst, San Francisco, CA 94158 USA

[2] Univ Calif San Francisco, Dept Med, San Francisco, CA 94158 USA

来源：

CELL METABOLISM | 2007年 / 6卷 / 02期

关键词：

D O I：

10.1016/j.cmet.2007.07.006

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Macrophages orchestrate an inflammatory response that contributes to glucose intolerance in diet-induced obesity and plaque instability in atherosclerosis. Within this heterogeneous group of cells are proinflammatory (M1) and anti-inflammatory (M2) macrophages. Recent work has identified the nuclear hormone receptor PPAR gamma as a critical signaling molecule in determining macrophage phenotype in vitro and in adipose tissue. In the current issue of Cell Metabolism, Bouhlel et al. (2007) extend this paradigm to the vessel wall by showing that both M1 and M2 macrophages are present in atherosclerotic lesions and that activation of PPAR gamma polarizes circulating blood monocytes to become M2 macrophages.

引用

收藏

页码：96 / 98

页数：3

相关论文

共 23 条

[1] IKK-β links inflammation to obesity-induced insulin resistance [J].

Arkan, MC ;

Hevener, AL ;

Greten, FR ;

Maeda, S ;

Li, ZW ;

Long, JM ;

Wynshaw-Boris, A ;

Poli, G ;

Olefsky, J ;

Karin, M .

NATURE MEDICINE, 2005, 11 (02) :191-198

[2] Conditional knockout of macrophage PPARγ increases atherosclerosis in C57BL/6 and low-density lipoprotein receptor-deficient mice [J].

Babaev, VR ;

Yancey, PG ;

Ryzhov, SV ;

Kon, V ;

Breyer, MD ;

Magnuson, MA ;

Fazio, S ;

Linton, MF .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2005, 25 (08) :1647-1653

[3] Oxidized lipid-driven chemokine receptor switch, CCR2 to CX3CR1, mediates adhesion of human macrophages to coronary artery smooth muscle cells through a peroxisome proliferator-activated receptor γ-dependent pathway [J].

Barlic, Jana ;

Zhang, Yuan ;

Foley, John F. ;

Murphy, Philip M. .

CIRCULATION, 2006, 114 (08) :807-819

[4] Decreased lesion formation in CCR2-/- mice reveals a role for chemokines in the initiation of atherosclerosis [J].

Boring, L ;

Gosling, J ;

Cleary, M ;

Charo, IF .

NATURE, 1998, 394 (6696) :894-897

[5] PPARγ activation primes human monocytes into alternative M2 macrophages with anti-inflammatory properties [J].

Bouhlel, M. Amine ;

Derudas, Bruno ;

Rigamonti, Elena ;

Dievart, Rebecca ;

Brozek, John ;

Haulon, Stephan ;

Zawadzki, Christophe ;

Jude, Brigitte ;

Torpier, Gerard ;

Marx, Nikolaus ;

Staels, Bart ;

Chinetti-Gbaguidi, Giulia .

CELL METABOLISM, 2007, 6 (02) :137-143

[6] A PPARγ-LXR-ABCA1 pathway in macrophages is involved in cholesterol efflux and atherogenesis [J].

Chawla, A ;

Boisvert, WA ;

Lee, CH ;

Laffitte, BA ;

Barak, Y ;

Joseph, SB ;

Liao, D ;

Nagy, L ;

Edwards, PA ;

Curtiss, LK ;

Evans, RM ;

Tontonoz, P .

MOLECULAR CELL, 2001, 7 (01) :161-171

[7] PPAR-γ dependent and independent effects on macrophage-gene expression in lipid metabolism and inflammation [J].

Chawla, A ;

Barak, Y ;

Nagy, L ;

Liao, D ;

Tontonoz, P ;

Evans, RM .

NATURE MEDICINE, 2001, 7 (01) :48-52

[8] Alternative activation of macrophages [J].

Gordon, S .

NATURE REVIEWS IMMUNOLOGY, 2003, 3 (01) :23-35

[9] Absence of monocyte chemoattractant protein-1 reduces atherosclerosis in low density lipoprotein receptor-deficient mice [J].

Gu, L ;

Okada, Y ;

Clinton, SK ;

Gerard, C ;

Sukhova, GK ;

Libby, P ;

Rollins, BJ .

MOLECULAR CELL, 1998, 2 (02) :275-281

[10] Oxidized LDL reduces monocyte CCR2 expression through pathways involving peroxisome proliferator-activated receptor γ [J].

Han, KH ;

Chang, MK ;

Boullier, A ;

Green, SR ;

Li, A ;

Glass, CK ;

Quehenberger, O .

JOURNAL OF CLINICAL INVESTIGATION, 2000, 106 (06) :793-802