Influence of temperature on enantioseparation employing an amylose-derivative stationary phase

被引：32

作者：

Kazusaki, M ^{[1
]}

Kawabata, H ^{[1
]}

Matsukura, H ^{[1
]}

机构：

[1] Dainippon Pharmaceut Co Ltd, Pharmaceut Res Labs, Dept Chem Anal, Fukushima Ku, Osaka 5530001, Japan

来源：

JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES | 2000年 / 23卷 / 19期

关键词：

D O I：

10.1081/JLC-100101834

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

In reversed-phase mode, chromatographic retention is investigated thermodynamically fur an enantiomeric pair on an amylose-derivative bonded phase. Ehthalpies and entropies of solute transfer (mobile to stationary phase) are calculated from retention data by evaluation of van't Hoff plots. Conformational change of the stationary phase is observed at about 20 degreesC. The enantioselectivity is exclusively driven by enthalpy above about 20 degreesC, whereas below about 20 degreesC enantioseparation was achieved by the combination of enthalpy and entropy. The inclusion process of the enantiomer, retained stronger on the stationary phase, plays a important role for chiral recognition on the amylose-derived stationary phase.

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页码：2937 / 2946

页数：10

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