Microwave-assisted one-pot synthesis of 2,3-disubstituted 3H-quinazolin-4-ones

被引：141

作者：

Liu, JF

Lee, JY

Dalton, AM

Bi, G

Yu, LB

Baldino, CM

McElory, E

Brown, M

机构：

[1] ArQule Inc, Div Chem Technol, Woburn, MA 01801 USA

[2] Pfizer Inc, Pfizer Global Res & Dev, Groton, CT 06340 USA

来源：

TETRAHEDRON LETTERS | 2005年 / 46卷 / 08期

关键词：

microwave; quinazolinone;

D O I：

10.1016/j.tetlet.2005.01.008

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A practical synthesis of 2,3-disubstituted 3H-quinazolin-4-ones 1 with broad chemistry scope is described. The key step is the microwave promoted one-pot, two-step reaction sequence combining anthranilic acids, carboxylic acids, and amines providing efficient access to this important class of heterocycles. (C) 2005 Elsevier Ltd. All rights reserved.

引用

页码：1241 / 1244

页数：4

共 17 条

[1]

BUZAS A, 1959, B SOC CHIM FR, P1889

[2] Quinazolin-4-one α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonists:: Structure-activity relationship of the C-2 side chain tether [J].