Nuclear matrix interactions within the sperm genome

被引：74

作者：

Kramer, JA ^{[1
]}

Krawetz, SA ^{[1
]}

机构：

[1] WAYNE STATE UNIV, SCH MED, CS MOTT CTR HUMAN GROWTH & DEV, DETROIT, MI 48102 USA

来源：

JOURNAL OF BIOLOGICAL CHEMISTRY | 1996年 / 271卷 / 20期

关键词：

D O I：

10.1074/jbc.271.20.11619

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Analysis of the haploid expressed human PRM1 --> PRM2 --> TNP2 genic domain has revealed two regions of attachment to the sperm nuclear matrix. These sperm nuclear matrix attachment regions delimit the DNase I-sensitive domain of this haploid expressed locus. The domain is intermediately associated with but not attached to the nuclear matrix. DNase I-sensitive genes within the mature sperm nucleus, such as protamine 1, protamine 2, transition protein 2, alpha-globin, and beta-actin, display this intermediate affinity for the sperm nuclear matrix. This may denote their role in templating the male genome prior to fertilization, thus ensuring the formation of a viable male pronucleus during early embryonic development.

引用

页码：11619 / 11622

页数：4

共 30 条

[1]

BARONE JG, 1994, J ANDROL, V15, P139

[2] MAPPING THE CELLS NUCLEUS [J].

BASKIN, Y .

SCIENCE, 1995, 268 (5217) :1564-1565

[3] NATURE OF DNA-SEQUENCES AT THE ATTACHMENT REGIONS OF GENES TO THE NUCLEAR MATRIX [J].

BOULIKAS, T .

JOURNAL OF CELLULAR BIOCHEMISTRY, 1993, 52 (01) :14-22

[4] A HAPLOID EXPRESSED GENE-CLUSTER EXISTS AS A SINGLE CHROMATIN DOMAIN IN HUMAN SPERM [J].

CHOUDHARY, SK ;

WYKES, SM ;

KRAMER, JA ;

MOHAMED, AN ;

KOPPITCH, F ;

NELSON, JE ;

KRAWETZ, SA .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (15) :8755-8762

[5]

CIEJEK EM, 1983, NATURE, V306, P607, DOI 10.1038/306607a0

[6] CHROMOSOMAL LOOP ANCHORAGE OF THE KAPPA IMMUNOGLOBULIN GENE OCCURS NEXT TO THE ENHANCER IN A REGION CONTAINING TOPOISOMERASE-II SITES [J].

COCKERILL, PN ;

GARRARD, WT .

CELL, 1986, 44 (02) :273-282

[7] CHICKEN HISTONE GENES RETAIN NUCLEAR MATRIX ASSOCIATION THROUGHOUT THE CELL-CYCLE [J].

DALTON, S ;

YOUNGHUSBAND, HB ;

WELLS, JRE .

NUCLEIC ACIDS RESEARCH, 1986, 14 (16) :6507-6523

[8] MATRIX ATTACHMENT REGIONS ARE POSITIONED NEAR REPLICATION INITIATION SITES, GENES, AND AN INTERAMPLICON JUNCTION IN THE AMPLIFIED DIHYDROFOLATE-REDUCTASE DOMAIN OF CHINESE-HAMSTER OVARY CELLS [J].

DIJKWEL, PA ;

HAMLIN, JL .

MOLECULAR AND CELLULAR BIOLOGY, 1988, 8 (12) :5398-5409

[9]

DOGGETT NA, 1995, NATURE, V377, P335

[10] NUCLEAR MATRIX PROTEINS REFLECT CELL TYPE OF ORIGIN IN CULTURED HUMAN-CELLS [J].

FEY, EG ;

PENMAN, S .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (01) :121-125

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