Administration of Pigment Epithelium-Derived Factor Inhibits Left Ventricular Remodeling and Improves Cardiac Function in Rats with Acute Myocardial Infarction

被引：57

作者：

Ueda, Shin-ichiro ^{[2
]}

Yamagishi, Sho-ichi ^{[1
]}

Matsui, Takanori ^{[1
]}

Jinnouchi, Yuko ^{[2
]}

Imaizumi, Tsutomu ^{[2
]}

机构：

[1] Kurume Univ, Sch Med, Dept Pathophysiol & Therapeut Diabet Vasc Complic, Kurume, Fukuoka 8300011, Japan

[2] Kurume Univ, Sch Med, Div Cardiovasc Med, Dept Med, Kurume, Fukuoka 8300011, Japan

来源：

AMERICAN JOURNAL OF PATHOLOGY | 2011年 / 178卷 / 02期

关键词：

OXYGEN SPECIES GENERATION; FACTOR PEDF; ENDOTHELIAL-CELLS; NADPH OXIDASE; OXIDATIVE STRESS; SERUM-LEVELS; EXPRESSION; SURVIVAL; GROWTH; INJURY;

D O I：

10.1016/j.ajpath.2010.10.018

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Oxidative stress and inflammation are involved in cardiac remodeling after acute myocardial infarction (AM!). We have found that pigment epithelium-derived factor (PEDF) inhibits vascular inflammation through its anti-oxidative properties. However, effects of PEDF on cardiac remodeling after AMI remain unknown. We investigated whether PEDF could inhibit left ventricular remodeling and improve cardiac function in rats with AMI. AMI was induced in 8-week-old Sprague-Dawley rats by ligation of the left ascending coronary artery. Rats were treated intravenously with vehicle or 10 mu g PEDF/100 g b.wt. every day for up to 2 weeks after AMI. Each rat was followed until 16 weeks of age. PEDF levels in infarcted areas and serum were significantly decreased at 1 week after AMI and remained low during the observational periods. PEDF administration inhibited apoptotic cell death and oxidative stress generation around the infarcted areas at 2 and 8 weeks after AMI. Further, PEDF injection suppressed cardiac fibrosis by reducing transforming growth factor-beta and type III collagen expression, improved left ventricular ejection fraction, ameliorated diastolic dysfunction, and inhibited the increase in left ventricular mass index at 8 weeks after AMI. The present study demonstrated that PEDF could inhibit tissue remodeling and improve cardiac function in AMI rats. Substitution of PEDF may be a novel therapeutic strategy for cardiac remodeling after AMI. (Am J Pathol 2011, 178:591-598. DOI. 10.10164/j.ajpath.2010.10.018)

引用

页码：591 / 598

页数：8

共 39 条

[1] ASPIRIN ENHANCES THE BENEFITS OF LATE REPERFUSION ON INFARCT SHAPE - A POSSIBLE MECHANISM OF THE BENEFICIAL-EFFECTS OF ASPIRIN ON SURVIVAL AFTER ACUTE MYOCARDIAL-INFARCTION [J].