A rapid stereocontrolled synthesis of the 3a-hydroxy-pyrrolo[2,3-b]indole skeleton, a building block for 10b-hydroxy-pyrazino[1′,2′:1,5]pyrrolo[2,3-b]indole-1,4-diones

被引:53
作者
Ley, SV [1 ]
Cleator, E [1 ]
Hewitt, PR [1 ]
机构
[1] Univ Cambridge, Dept Chem, Cambridge CB2 1EW, England
关键词
5-N-ACETYLARDEEMIN; OXYGENATION; DERIVATIVES; TRYPTOPHAN; AMAUROMINE;
D O I
10.1039/b308288a
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A two-step selenocyclisation-oxidative deselenation sequence was used to establish the 3a-hydroxy-pyrrolo-[2,3-b]indole core; these tricycles were used as effective precursors to 10b-hydroxy-pyrazino[1',2' : 1,5]pyrrolo-[2,3-b]indole-1,4-diones.
引用
收藏
页码:3492 / 3494
页数:3
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