Expression of zebrafish btg-b, an anti-proliferative cofactor, during early embryogenesis

被引：11

作者：

Sakaguchi, T

Kuroiwa, A

Takeda, H ^{[1
]}

机构：

[1] Natl Inst Genet, Div Early Embryogenesis, Shizuoka 4118540, Japan

[2] Natl Inst Genet, Grad Univ Adv Studies, Shizuoka 4118540, Japan

[3] Nagoya Univ, Grad Sch Sci, Div Biol Sci, Chikusa Ku, Nagoya, Aichi 4648602, Japan

来源：

MECHANISMS OF DEVELOPMENT | 2001年 / 104卷 / 1-2期

关键词：

zebrafish; btg-b; Btg2; Hoxb9;

D O I：

10.1016/S0925-4773(01)00374-4

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

BTG/tob family proteins are thought to be a potential tumor suppressor due to their anti-proliferative activity. We cloned zebrafish btg-b, a member of the BTG1/2 subfamily, using in situ hybridization screening. The tissue-specific expression of brg-b is first observed in the organizer region at the early gastrula stage. Later in development, the forebrain, the hindbrain, the polster and the paraxial mesoderm transiently express btg-b. Recently, mouse Btg1 and Btg2 have been shown to be a cofactor for Hoxb9. Double in situ hybridization with zebrafish btg-b and hoxb9a indicates that the expression domains of these two genes overlap in the posterior paraxial mesoderm. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：113 / 115

页数：3

共 10 条

[1] Arrest of G1-S progression by the p53-inducible gene PC3 is Rb dependent and relies on the inhibition of cyclin D1 transcription [J].