Premotor transcranial direct current stimulation (tDCS) affects primary motor excitability in humans

被引:163
作者
Boros, Klara [1 ]
Poreisz, Csaba [1 ]
Muenchau, Alexander [2 ]
Paulus, Walter [1 ]
Nitsche, Michael A. [1 ]
机构
[1] Univ Gottingen, Dept Clin Neurophysiol, D-37075 Gottingen, Germany
[2] Univ Med Hamburg Eppendorf, Dept Neurol, Hamburg, Germany
关键词
dorsolateral prefrontal cortex (DLPFC); premotor cortex (PM); short intracortical inhibition and facilitation (SICI/ICF); transcranial direct current stimulation (tDCS); transcranial magnetic stimulation (TMS);
D O I
10.1111/j.1460-9568.2008.06090.x
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Recent studies have shown that repetitive transcranial magnetic stimulation (rTMS) over the premotor cortex (PM) modifies the excitability of the ipsilateral primary motor cortex (M1). Transcranial direct current stimulation (tDCS) is a new method to induce neuroplasticity in humans non-invasively. tDCS generates neuroplasticity directly in the cortical area under the electrode, but might also induce effects in distant brain areas, caused by activity modulation of interconnected areas. However, this has not yet been tested electrophysiologically. We aimed to study whether premotor tDCS can modify the excitability of the ipsilateral M1 via cortico-cortical connectivity. Sixteen subjects received cathodal and anodal tDCS of the PM and eight subjects of the dorsolateral prefrontal cortex. Premotor anodal, but not premotor cathodal or prefrontal tDCS, modified selectively short intracortical inhibition/intracortical facilitation (SICI/ICF), while motor thresholds, single test-pulse motor-evoked potential and input-output curves were stable throughout the experiments. Specifically, anodal tDCS decreased intracortical inhibition and increased paired-pulse excitability. The selective influence of premotor tDCS on intracortical excitability of the ipsilateral M1 suggests a connectivity-driven effect of tDCS on remote cortical areas. Moreover, this finding indirectly substantiates the efficacy of tDCS to modulate premotor excitability, which might be of interest for applications in diseases accompanied by pathological premotor activity.
引用
收藏
页码:1292 / 1300
页数:9
相关论文
共 29 条
[1]   Repeated premotor rTMS leads to cumulative plastic changes of motor cortex excitability in humans [J].
Bäumer, T ;
Lange, R ;
Liepert, J ;
Weiller, C ;
Siebner, HR ;
Rothwell, JC ;
Münchau, A .
NEUROIMAGE, 2003, 20 (01) :550-560
[2]   Abnormal excitability of premotor-motor connections in de novo Parkinson's disease [J].
Buhmann, C ;
Gorsler, A ;
Bäumer, T ;
Hidding, U ;
Demiralay, C ;
Hinkelmann, K ;
Weiller, C ;
Siebner, HR ;
Münchau, A .
BRAIN, 2004, 127 :2732-2746
[3]  
Chen R, 2000, MUSCLE NERVE, pS26
[4]   Transcranial magnetic stimulation can be used to test connections to primary motor areas from frontal and medial cortex in humans [J].
Civardi, C ;
Cantello, R ;
Asselman, P ;
Rothwell, JC .
NEUROIMAGE, 2001, 14 (06) :1444-1453
[5]   Multiple nonprimary motor areas in the human cortex [J].
Fink, GR ;
Frackowiak, RSJ ;
Pietrzyk, U ;
Passingham, RE .
JOURNAL OF NEUROPHYSIOLOGY, 1997, 77 (04) :2164-2174
[6]   Anodal transcranial direct current stimulation of prefrontal cortex enhances working memory [J].
Fregni, F ;
Boggio, PS ;
Nitsche, M ;
Bermpohl, F ;
Antal, A ;
Feredoes, E ;
Marcolin, MA ;
Rigonatti, SP ;
Silva, MTA ;
Paulus, W ;
Pascual-Leone, A .
EXPERIMENTAL BRAIN RESEARCH, 2005, 166 (01) :23-30
[7]   Stimulation over the human supplementary motor area interferes with the organization of future elements in complex motor sequences [J].
Gerloff, C ;
Corwell, B ;
Chen, R ;
Hallett, M ;
Cohen, LG .
BRAIN, 1997, 120 :1587-1602
[8]   Decreased corticospinal excitability after subthreshold 1 Hz rTMS over lateral premotor cortex [J].
Gerschlager, W ;
Siebner, HR ;
Rothwell, JC .
NEUROLOGY, 2001, 57 (03) :449-455
[9]   CORTICOCORTICAL SYNAPTIC INFLUENCES ON MORPHOLOGICALLY IDENTIFIED PYRAMIDAL NEURONS IN THE MOTOR CORTEX OF THE MONKEY [J].
GHOSH, S ;
PORTER, R .
JOURNAL OF PHYSIOLOGY-LONDON, 1988, 400 :617-+
[10]   Using the International 10-20 EEG system for positioning of transcranial magnetic stimulation [J].
Herwig, U ;
Satrapi, P ;
Schönfeldt-Lecuona, C .
BRAIN TOPOGRAPHY, 2003, 16 (02) :95-99