General anesthetic effects on protein kinase C

被引：32

作者：

Hemmings, HC

机构：

[1] Cornell Univ, Coll Med, Dept Anesthesiol, New York, NY 10021 USA

[2] Cornell Univ, Coll Med, Dept Pharmacol, New York, NY 10021 USA

来源：

TOXICOLOGY LETTERS | 1998年 / 101卷

关键词：

anesthesia; protein kinase c; cellular effect; molecular mechanism;

D O I：

10.1016/S0378-4274(98)00170-2

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 [卫生毒理学];

摘要：

(1) Protein kinase C is a family of phospholipid-dependent protein kinases which are involved in the regulation of diverse cellular functions. (2) Evidence is emerging that certain general anesthetics can stimulate the activity of protein kinase C by interacting with the regulatory domain of the enzyme, possibly with the diacylglycerol binding sites. Anesthetics also potentiate activation-dependent down-regulation of the enzyme. (3) A role for PKC in the mediation and/or modulation of the cellular effects of general anesthetics is a potential molecular target for anesthetic action. (C) 1998 Published by Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：89 / 95

页数：7

共 32 条

[1]

ARAKI M, 1994, ANESTH ANALG, V79, P267

[2]

BELL RM, 1991, J BIOL CHEM, V266, P4661

[3]

BONI LT, 1985, J BIOL CHEM, V260, P819

[4]

PROTEIN-KINASE C-ALPHA,DELTA,EPSILON AND ZETA IN C-6 GLIOMA-CELLS - TPA INDUCES TRANSLOCATION AND DOWN-REGULATION OF CONVENTIONAL AND NEW PKC ISOFORMS BUT NOT ATYPICAL PKC-ZETA [J].