Prevalence of Estrogen Receptor Alpha PvuII (c454-397T>C) and XbaI (c454A>G) Polymorphisms in a Population of Brazilian Women

被引：10

作者：

Araujo, Karine Lourenzone ^{[1
]}

Dias de Rezende, Lucas Cunha ^{[1
]}

Souza, Leticia Soncini ^{[1
,2
]}

Daltoe, Renata Dalmaschio ^{[1
,3
]}

Madeira, Klesia Pirola ^{[1
,3
]}

Paes, Marcela Ferreira ^{[1
,3
]}

Herkenhoff, Fernando Luiz ^{[2
,4
]}

Azevedo Rangel, Leticia Batista ^{[1
,3
]}

Silva, Ian Victor ^{[1
,2
]}

机构：

[1] Univ Fed Espirito Santo, Programa Pos Grad Biotecnol, Vitoria, ES, Brazil

[2] Univ Fed Espirito Santo, Lab Biol Celular Envelhecimento, Dept Morfol, Vitoria, ES, Brazil

[3] Univ Fed Espirito Santo, Lab Biol Celular & Mol Canc Humano, Dept Ciencias Farmaceut, Vitoria, Espirito Santo, Brazil

[4] Univ Fed Espirito Santo, Programa Pos Grad Ciencias Fisiol, Vitoria, ES, Brazil

来源：

BRAZILIAN ARCHIVES OF BIOLOGY AND TECHNOLOGY | 2011年 / 54卷 / 06期

关键词：

Polymorphism; Estrogen Receptor; Brazilian Women; Prevalence; Linkage disequilibrium; BONE-MINERAL DENSITY; GENE POLYMORPHISMS; BREAST-CANCER; RISK-FACTORS; ASSOCIATION; HEART; EXPRESSION;

D O I：

10.1590/S1516-89132011000600010

中图分类号：

Q [生物科学];

学科分类号：

090105 [作物生产系统与生态工程];

摘要：

The aim of this work was to study the estrogen receptor alpha (ERS1) PvuII and XbaI gene polymorphisms prevalence in randomly selected women population from Rio de Janeiro and Esprito Santo states in Brazil by polymerase chain reaction restriction fragment lengths polymorphism (PCR RFLP) methodology. It was shown that Rio de Janeiro women exhibited a significantly different prevalence of XbaI polymorphism comparing to Espirito Santo women. Nonetheless, similar prevalence of PvuII polymorphism was found in both women's populations. Moreover, a strong linkage disequilibrium was observed between these SNPs reinforcing the hypothesis of differential pattern of inheritance observed on such populations.

引用

页码：1151 / 1157

页数：7

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Prevalence of Estrogen Receptor Alpha PvuII (c454-397T&gt;C) and XbaI (c454A&gt;G) Polymorphisms in a Population of Brazilian Women

Prevalence of Estrogen Receptor Alpha PvuII (c454-397T>C) and XbaI (c454A>G) Polymorphisms in a Population of Brazilian Women