Critical assessment of methods of protein structure prediction (CASP) - Round 6

被引:125
作者
Moult, J
Fidelis, K
Rost, B
Hubbard, T
Tramontano, A
机构
[1] Univ Maryland, Inst Biotechnol, Ctr Adv Res Biotechnol, Rockville, MD 20850 USA
[2] Lawrence Livermore Natl Lab, Biol & Biotechnol Res Program, Livermore, CA USA
[3] Univ Roma La Sapienza, Inst Pasteur, Fdn Cenci Bolognetti, Rome, Italy
[4] Columbia Univ, CUBIC, Dept Biochem & Mol Biophys, New York, NY USA
关键词
protein structure prediction; community-wide experiment; CASP;
D O I
10.1002/prot.20716
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
This article is an introduction to the special issue of the journal Proteins, dedicated to the sixth CASP experiment to assess the state of the art in protein structure prediction. The article describes the conduct of the experiment and the categories of prediction included, and outlines the evaluation and assessment procedures. A brief summary of progress over the decade of CASP experiments is also provided.
引用
收藏
页码:3 / 7
页数:5
相关论文
共 15 条
[1]  
Bourne Philip E, 2003, Methods Biochem Anal, V44, P501
[2]   Ten years of predictions ... and counting [J].
Cozzetto, D ;
Di Matteo, A ;
Tramontano, A .
FEBS JOURNAL, 2005, 272 (04) :881-882
[3]  
Dyson HJ, 2002, ADV PROTEIN CHEM, V62, P311
[4]   CASP6 data processing and automatic evaluation at the protein structure prediction center [J].
Kryshtafovych, A ;
Milostan, M ;
Szajkowski, L ;
Daniluk, P ;
Fidelis, K .
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 2005, 61 :19-23
[5]   Progress over the first decade of CASP experiments [J].
Kryshtafovych, A ;
Venclovas, C ;
Fidelis, K ;
Moult, J .
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 2005, 61 :225-236
[6]   A decade of CASP: progress, bottlenecks and prognosis in protein structure prediction [J].
Moult, J .
CURRENT OPINION IN STRUCTURAL BIOLOGY, 2005, 15 (03) :285-289
[7]   Critical assessment of methods of protein structure prediction (CASP)-round V [J].
Moult, J ;
Fidelis, K ;
Zemla, A ;
Hubbard, T .
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 2003, 53 :334-339
[8]  
Moult J, 1999, PROTEINS, P2
[9]   A LARGE-SCALE EXPERIMENT TO ASSESS PROTEIN-STRUCTURE PREDICTION METHODS [J].
MOULT, J ;
PEDERSEN, JT ;
JUDSON, R ;
FIDELIS, K .
PROTEINS-STRUCTURE FUNCTION AND GENETICS, 1995, 23 (03) :R2-R4
[10]  
Moult J, 1997, PROTEINS, P2