Intrahippocampal insulin improves memory in a passive-avoidance task in male wistar rats

被引：62

作者：

Babri, Shirin ^{[1
]}

Badie, Hamid Gholamipour ^{[1
]}

Khamenei, Saeed ^{[1
]}

Seyedlar, Mehdi Ordikhani ^{[1
]}

机构：

[1] Tabriz Univ Med Sci, Drug Appl Res Ctr, Tabriz, Iran

来源：

BRAIN AND COGNITION | 2007年 / 64卷 / 01期

关键词：

insulin; memory; passive avoidance; intrahippocampal; rat;

D O I：

10.1016/j.bandc.2007.01.002

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The main impacts of insulin favor the peripheral organs. Although it functions as a neuropeptide, insulin possesses also some central effects. The aim of this study was to determine the effect of intrahippocampal infusion of insulin on passive avoidance learning in healthy male rats. Thirty male wistar rats were divided into three groups (n = 10 each). The experimental group had posttraining insulin infusion into the CAI region of dorsal hippocampus, after which they were compared with sham (saline) and control (intact) groups. Insulin treated animals had greater latency to enter the dark compartment in compare with saline treated (p=0.023) or control groups (p=0.017). Upon our results, we concluded that intrahippocampal injections of insulin may enhance memory for a simple learning task which supports the concept that insulin possibly plays an endogenous role in memory formation. (C) 2007 Elsevier Inc. All rights reserved.

引用

页码：86 / 91

页数：6

共 56 条

[1] BRAIN PROTEIN-PHOSPHORYLATION INVITRO - SELECTIVE SUBSTRATE ACTION OF INSULIN [J].