Chronic eosinophilic leukemias and the myeloproliferative variant of the hypereosinophilic syndrome

被引：51

作者：

Bain, Barbara J. ^{[1
]}

Fletcher, Sarah H. ^{[1
]}

机构：

[1] St Marys Hosp, Imperial Coll Fac med, Dept Haematol, London W2 1NY, England

来源：

IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA | 2007年 / 27卷 / 03期

关键词：

D O I：

10.1016/j.iac.2007.06.001

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Among patients with hypereosinophilia, a myeloproliferative variant is recognized. In many of these patients a diagnosis of eosinophilic leukemia can be made. The molecular mechanism is often a fusion gene, incorporating part of PDGFRA or PDGFRB, encoding anaberrant tyrosine kinase. Prompt diagnosis of such cases is important since specific tyrosine kinase inhibitor therapy is indicated.

引用

页码：377 / +

页数：13

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