Reduced neuronal efficacy in progressive mild cognitive impairment: A prospective fMRI study on visuospatial processing

被引:77
作者
Vannini, Patrizia
Almkvist, Ove
Dierks, Thomas
Lehmann, Christoph
Wahlund, Lars-Olof
机构
[1] Karolinska Huddinge Univ Hosp, Karolinska Inst, Dept Neurobiol Care Sci & Soc, Div Clin Geriat, S-14186 Huddinge, Sweden
[2] Univ Stockholm, Dept Psychol, S-10691 Stockholm, Sweden
[3] Univ Bern, Hosp Psychiat, Dept Psychiat & Neurophysiol, CH-3000 Bern, Switzerland
基金
瑞典研究理事会;
关键词
preclinical Alzheimer's disease; angle discrimination; reaction time;
D O I
10.1016/j.pscychresns.2007.02.003
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Mild cognitive impairment (MCI) often refers to the preclinical stage of dementia, where the majority develop Alzheimer's disease (AD). Given that neurodegenerative burden and compensatory mechanisms might exist before accepted clinical symptoms of AD are noticeable, the current prospective study aimed to investigate the functioning of brain regions in the visuospatial networks responsible for preclinical symptoms in AD using event-related functional magnetic resonance imaging (fMRI). Eighteen MCI patients were evaluated and clinically followed for approximately 3 years. Five progressed to AD (PMCI) and eight remained stable (SMCI). Thirteen age-, gender- and education-matched controls also participated. An angle discrimination task with varying task demands was used. Brain activation patterns as well as task demand-dependent and -independent signal changes between the groups were investigated by using an extended general linear model including individual performance (reaction time [RT]) of each single trial. Similar behavioral (RT and accuracy) responses were observed between MCI patients and controls. A network of bilateral activations, e.g. dorsal pathway, which increased linearly with increasing task demand, was engaged in all subjects. Compared with SMCI patients and controls, PMCI patients showed a stronger relation between task demand and brain activity in left superior parietal lobules (SPL) as well as a general task demand-independent increased activation in left precuneus. Altered brain function can be detected at a group level in individuals that progress to AD before changes occur at the behavioral level. Increased parictal activation in PMCI could reflect a reduced neuronal efficacy due to accumulating AD pathology and might predict future clinical decline in patients with MCI. (c) 2007 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:43 / 57
页数:15
相关论文
共 51 条
[1]
BINOMIAL DISTRIBUTION OF RIGHT MIXED AND LEFT HANDEDNESS [J].
ANNETT, M .
QUARTERLY JOURNAL OF EXPERIMENTAL PSYCHOLOGY, 1967, 19 :327-&
[2]
Cortical distribution of neurofibrillary tangles in Alzheimer's disease matches the pattern of neurons that retain their capacity of plastic remodelling in the adult brain [J].
Arendt, T ;
Brückner, MK ;
Gertz, HJ ;
Marcova, L .
NEUROSCIENCE, 1998, 83 (04) :991-1002
[3]
Impaired cerebral glucose metabolism and cognitive functioning predict deterioration in mild cognitive impairment [J].
Arnáiz, E ;
Jelic, V ;
Almkvist, O ;
Wahlund, LO ;
Winblad, B ;
Valind, S ;
Nordberg, A .
NEUROREPORT, 2001, 12 (04) :851-855
[4]
Arnáiz E, 2000, ALZHEIMERS REP, V3, P97
[5]
TIME COURSE EPI OF HUMAN BRAIN-FUNCTION DURING TASK ACTIVATION [J].
BANDETTINI, PA ;
WONG, EC ;
HINKS, RS ;
TIKOFSKY, RS ;
HYDE, JS .
MAGNETIC RESONANCE IN MEDICINE, 1992, 25 (02) :390-397
[6]
Episodic memory changes are associated with the APOE-epsilon 4 allele in nondemented older adults [J].
Bondi, MW ;
Salmon, DP ;
Monsch, AU ;
Galasko, D ;
Butters, N ;
Klauber, MR ;
Thal, LJ ;
Saitoh, T .
NEUROLOGY, 1995, 45 (12) :2203-2206
[7]
Patterns of brain activation in people at risk for Alzheimer's disease [J].
Bookheimer, SY ;
Strojwas, MH ;
Cohen, MS ;
Saunders, AM ;
Pericak-Vance, MA ;
Mazziotta, JC ;
Small, GW .
NEW ENGLAND JOURNAL OF MEDICINE, 2000, 343 (07) :450-456
[8]
BRIGGS G G, 1975, Cortex, V11, P230
[9]
Characterizing stimulus-response functions using nonlinear regressors in parametric fMRI experiments [J].
Buchel, C ;
Holmes, AP ;
Rees, G ;
Friston, KJ .
NEUROIMAGE, 1998, 8 (02) :140-148
[10]
Nonlinear regression in parametric activation studies [J].
Buchel, C ;
Wise, RJS ;
Mummery, CJ ;
Poline, JB ;
Friston, KJ .
NEUROIMAGE, 1996, 4 (01) :60-66