Solvatochromism, DNA binding, antitumor activity and molecular modeling study of mixed-ligand copper(II) complexes containing the bulky ligand:: Bis[N-(p-tolyl)imino]acenaphthene

被引：42

作者：

El-Ayaan, Usama ^{[1
,2
]}

Abdel-Aziz, Alaa A. -M. ^{[3
]}

Al-Shihry, Shar ^{[1
]}

机构：

[1] King Faisal Univ, Coll Sci, Dept Chem, Al Hufuf 31982, Saudi Arabia

[2] Mansoura Univ, Fac Sci, Dept Chem, Mansoura 35516, Egypt

[3] King Saud Univ, Coll Pharm, Dept Pharmaceut Chem, Riyadh 11451, Saudi Arabia

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2007年 / 42卷 / 11-12期

关键词：

solvatochromism; bis[N-(p-tolyl)imino]acenaphthene; DNA binding; molecular modeling;

D O I：

10.1016/j.ejmech.2007.02.014

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

Four mixed-ligand copper(H) complexes of the nitrogen ligand bis[N-(p-tolyl)imino]acenaphthene 1 (p-Tol-BIAN). These complexes, namely [Cu(p-Tol-BIAN)(2)](ClO4)(2) 2, [Cu(p-Tol-BIAN)(acac)](ClO4) 3, [Cu(p-Tol-BIAN)Cl-2] 4 and [Cu(p-Tol-BIAN)(AcOH)(2)](ClO4)(2) 5, were prepared and characterized. Solvatochromism of the novel copper complexes in various solvents has been studied. Molecular mechanics (MM+) and molecular dynamic simulations have been performed to learn more about the solvatochromic behaviour and the DNA binding affinity of these complexes. (C) 2007 Elsevier Masson SAS. All rights reserved.

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页码：1325 / 1333

页数：9

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