Coating Optimization of Superparamagnetic Iron Oxide Nanoparticles for High T2 Relaxivity

被引：366

作者：

Tong, Sheng

Hou, Sijian

Zheng, Zhilan

Zhou, Jun

Bao, Gang ^{[1
]}

机构：

[1] Georgia Inst Technol, Dept Biomed Engn, Atlanta, GA 30332 USA

来源：

NANO LETTERS | 2010年 / 10卷 / 11期

基金：

美国国家卫生研究院;

关键词：

SPIO; MRI contrast agent; nuclear relaxation; molecular imaging; MAGNETIC NANOPARTICLES; CONTRAST AGENTS; NANOCRYSTALS; MRI; ANGIOGENESIS; EXCHANGE; DELIVERY; SIZE;

D O I：

10.1021/nl102623x

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We describe a new method for coating superparamagnetic iron oxide nanoparticles (SPIOs) and demonstrate that, by One-tuning the core size and PEG coating of SPIOs, the T-2 relaxivity per particle can be increased by >200-Fold. With 14 nm core and PEG1000 coating, SPIOs can have T-2 relaxivity of 385 s(-1) mM(-1), which is among the highest per-Fe atom relaxivities. In vivo tumor imaging results demonstrated the potential of the SPIOs for clinical applications.

引用

收藏

页码：4607 / 4613

页数：7

相关论文

共 34 条

[1] Use of intravascular contrast agents in MRI [J].

Bjornerud, A ;

Wendland, MF ;

Johansson, L ;

Ahlstrom, HK ;

Higgins, CB ;

Oksendal, A .

ACADEMIC RADIOLOGY, 1998, 5 :S223-S225

[2] On T2-shortening by weakly magnetized particles:: The chemical exchange model [J].

Brooks, RA ;

Moiny, F ;

Gillis, P .

MAGNETIC RESONANCE IN MEDICINE, 2001, 45 (06) :1014-1020

[3] Angiogenesis in health and disease [J].

Carmeliet, P .

NATURE MEDICINE, 2003, 9 (06) :653-660

[4] In vivo imaging of quantum dots encapsulated in phospholipid micelles [J].

Dubertret, B ;

Skourides, P ;

Norris, DJ ;

Noireaux, V ;

Brivanlou, AH ;

Libchaber, A .

SCIENCE, 2002, 298 (5599) :1759-1762

[5] TRANSVERSE RELAXATION OF SOLVENT PROTONS INDUCED BY MAGNETIZED SPHERES - APPLICATION TO FERRITIN, ERYTHROCYTES, AND MAGNETITE [J].

GILLIS, P ;

KOENIG, SH .

MAGNETIC RESONANCE IN MEDICINE, 1987, 5 (04) :323-345

[6] On T2-shortening by strongly magnetized spheres:: A partial refocusing model [J].

Gillis, P ;

Moiny, F ;

Brooks, RA .

MAGNETIC RESONANCE IN MEDICINE, 2002, 47 (02) :257-263

[7] Magnetic resonance relaxation properties of superparamagnetic particles [J].

Gossuin, Yves ;

Gillis, Pierre ;

Hocq, Aline ;

Vuong, Quoc L. ;

Roch, Alain .

WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY, 2009, 1 (03) :299-310

[8] Surface modified superparamagnetic nanoparticles for drug delivery: Interaction studies with human fibroblasts in culture [J].

Gupta, AK ;

Curtis, ASG .

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 2004, 15 (04) :493-496

[9] Spherical micelles and other self-assembled structures in dilute aqueous mixtures of poly(ethylene glycol) lipids [J].

Johnsson, M ;

Hansson, P ;

Edwards, K .

JOURNAL OF PHYSICAL CHEMISTRY B, 2001, 105 (35) :8420-8430

[10] Nanoscaling laws of magnetic nanoparticles and their applicabilities in biomedical sciences [J].

Jun, Young-Wook ;

Seo, Jung-Wook ;

Cheon, Anw .

ACCOUNTS OF CHEMICAL RESEARCH, 2008, 41 (02) :179-189

← 1 2 3 4 →