Mulberry extract inhibits the development of atherosclerosis in cholesterol-fed rabbits

被引:84
作者
Chen, CC
Liu, LK
Hsu, JD
Huang, HP
Yang, MY
Wang, CJ
机构
[1] Chung Shan Med Univ, Coll Med, Inst Biochem, Taichung 402, Taiwan
[2] Chung Shan Med Univ Hosp, Coll Med, Dept Pathol, Taichung, Taiwan
关键词
Mulberry water extract; anti-hyperlipidemia; atherosclerosis; cholesterol-fed rabbit;
D O I
10.1016/j.foodchem.2004.06.039
中图分类号
O69 [应用化学];
学科分类号
081704 ;
摘要
Mulberry (Morus alba L.) fruit is used effectively in Chinese medicines against fever, to protect the liver and to lower blood pressure. Here, we report a water extract, MWE (Mulberry water extract), which is designed to exhibit anti-hyperlipidemia and atherosclerotic effects in rabbits with experimental atherosclerosis. New Zealand white rabbits were fed with a normal diet, high cholesterol (1.3%), lard oil (3%) diet (HCD) with or without 0.5 or 1% MWE for 10 weeks. The levels of triglyceride, cholesterol and low-density lipoprotein cholesterol (LDL-C) were lower in the serum of rabbits fed HCD plus MWE than in the serum of rabbits fed HCD. Feeding MWE (0.5 or 1% in the diet) to rabbits significantly reduced severe atherosclerosis in the aorta by 42-63%. Histopathological examination showed that MWE reduced aortic atherosclerotic lesion in the blood vessel of rabbits. From previous data and present results, we suspect that MWE not only inhibits LDL-oxidation but also has a direct effect on the anti-hyperlipidemia in animals. (C) 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码:601 / 607
页数:7
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