'One-pot' nitro reduction-cyclisation solid phase route to benzimidazoles

被引:114
作者
Wu, ZM [1 ]
Rea, P [1 ]
Wickham, G [1 ]
机构
[1] Mimotopes Pty Ltd, Clayton, Vic 3168, Australia
关键词
solid phase synthesis; benzimidazole; SynPhase (TM) Lantern;
D O I
10.1016/S0040-4039(00)01732-9
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
An improved solid phase synthesis of benzimidazoles is described. A polymer-bound o-nitroaniline was reacted with aldehydes in DMF in the presence of SnCl(2)(.)2H(2)O at 60 degreesC for three hours to give benzimidazoles in excellent purity and good yield after TFA cleavage. A library of 25 benzimidazoles was prepared using this 'one-pot' procedure. (C) 2000 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:9871 / 9874
页数:4
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