Clinical aspects of epidermodysplasia verruciformis

被引:57
作者
de Oliveira, WRP
Neto, CF
Rady, PL
Tyring, SK
机构
[1] Univ Sao Paulo, Dept Dermatol, Sao Paulo, Brazil
[2] Univ Texas, Med Branch, Dept Immunol & Microbiol, Galveston, TX 77550 USA
[3] Univ Texas, Med Branch, Dept Dermatol, Galveston, TX 77550 USA
关键词
epidermodysplasia verruciformis; genodermatosis; human papillomavirus; skin cancer;
D O I
10.1046/j.1468-3083.2003.00703.x
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Thirteen patients with epidermodysplasia verruciformis (EV) were studied over a period of 7 years. EV is a rare genodermatosis characterized by a generalized infection with a specific group of human papilloma virus (HPV) and a propensity for developing skin malignant tumours in 30%-50% of patients. The diagnosis of EV was confirmed by histopathological and immunohistochemical findings. Three of our patients had the benign form of EV, which is characterized by monomorphous lesions and no malignant changes, whereas 10 had the malignant form, which is characterized by polymorphic lesions and development of cutaneous malignant tumours. All EV patients with the malignant form developed multiple skin tumours (77%). They started to appear at age 20, predominantly on the forehead (50%). Most were squamous cell carcinoma, extremely aggressive and invasive, which provoked metastasis and death in two patients.
引用
收藏
页码:394 / 398
页数:5
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