Hydrogel implants for methotrexate obtained by ionizing radiation

被引：15

作者：

Beyssac, E

Bregni, C

Aiache, JM

Gerula, S

Smolko, E

机构：

[1] UNIV BUENOS AIRES,DEPT PHARMACEUT TECHNOL,FAC PHARM & BIOCHEM,BUENOS AIRES,DF,ARGENTINA

[2] FAC PHARM,BIOPHARMACEUT DEPT,F-63000 CLERMONT FERRAN,FRANCE

[3] EZEIZA ATOM CTR,CNEA,BUENOS AIRES,DF,ARGENTINA

来源：

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY | 1996年 / 22卷 / 05期

关键词：

D O I：

10.3109/03639049609069352

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The characteristics of poly (2-hydroxyethyl methaclylate) matrices for the controlled release of drugs have been investigated using methotrexate (MTX) as a model drug. Radiation-induced polymerization of hydrophilic monomers (HEMA and related compounds) at low temperature (-78 degrees C) was performed to immobilize MTX in the polymer matrix. The effect of the drug loading and different amounts of cross-linking agent on the in vitro drug release was studied in this work. The diffusion of MTX from the hydrogel matrices was proportional to the square root of the time, according to the equation proposed by Higuchi (1).

引用

页码：439 / 444

页数：6

共 7 条

[1]

BOUWSTRA JA, 1993, ENCY PHARM TECHNOLOG

[2]

DEGIORGI CF, IN PRESS J CONTROLLE

[3]

DOELKER E, 1987, STP PHARM, V3, P207

[4] MECHANISM OF SUSTAINED-ACTION MEDICATION - THEORETICAL ANALYSIS OF RATE OF RELEASE OF SOLID DRUGS DISPERSED IN SOLID MATRICES [J].