Biosynthesis and processing of endogenous BDNF: CNS neurons store and secrete BDNF, not pro-BDNF

被引：279

作者：

Matsumoto, Tomoya ^{[1
]}

Rauskolb, Stefanie ^{[1
]}

Polack, Martin ^{[2
]}

Klose, Johannes ^{[3
]}

Kolbeck, Roland ^{[3
,4
]}

Korte, Martin ^{[2
]}

Barde, Yves-Alain ^{[1
,3
]}

机构：

[1] Univ Basel, Biozentrum, CH-4056 Basel, Switzerland

[2] Tech Univ Carolo Wilhelmina Braunschweig, D-38106 Braunschweig, Germany

[3] Max Planck Inst Neurobiol, D-82152 Martinsried, Germany

[4] Medimmune Inc, Gaithersburg, MD 20878 USA

来源：

NATURE NEUROSCIENCE | 2008年 / 11卷 / 02期

关键词：

D O I：

10.1038/nn2038

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Pro- and mature BDNF activate very different receptors and intracellular pathways, potentially leading to either neuronal death or survival. Here we examined the biochemistry of endogenous BDNF in mouse neurons using sensitive reagents and found that pro-BDNF is rapidly converted intracellularly to mature BDNF, the latter being stored and released by excitatory input.

引用

页码：131 / 133

页数：3

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