MK-801 does not enhance dopaminergic cell survival in embryonic nigral grafts

被引：17

作者：

Schierle, GS ^{[1
]}

Karlsson, J ^{[1
]}

Brundin, P ^{[1
]}

机构：

[1] Lund Univ, Dept Physiol & Neurosci, Wallenberg Neurosci Ctr, Sect Neuronal Survival, S-22362 Lund, Sweden

来源：

NEUROREPORT | 1998年 / 9卷 / 07期

关键词：

dopamine; excitotoxicity; intracerebral transplantation; MK-801; Parkinson's disease;

D O I：

10.1097/00001756-199805110-00011

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Two groups of hemiparkinsonian rats received grafts of embryonic ventral mesencephalon with or without the addition of the NMDA receptor antagonist (+)dizocilpine hydrogen maleate (MK-801). When added to the cell suspension, a 10 mu M concentration of MK-801 did not enhance the survival of tyrosine hydroxylase positive neurones in the grafts. These findings suggest that cell death occurring during nigral transplantation is not primarily due to excitotoxicity. (C) 1998 Rapid Science Ltd.

引用

页码：1313 / 1316

页数：4

共 27 条

[1] ESTIMATION OF NUCLEAR POPULATION FROM MICROTOME SECTIONS [J].