A mild and selective method for the hydrolysis of esters with trimethyltin hydroxide

被引：314

作者：

Nicolaou, KC

Estrada, AA

Zak, M

Lee, SH

Safina, BS

机构：

[1] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA

[2] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA

[3] Univ Calif San Diego, Dept Chem & Biochem, La Jolla, CA 92093 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 09期

关键词：

D O I：

10.1002/anie.200462207

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Mild, selective, and efficient: A new method that involves the use of trimethyltin hydroxide for the hydrolysis of specific ester groups allows chemists to steer clear of unwanted elimination reactions and epimerizations. For example, the conversion of ester 1 into carboxylic acid 2 takes place under mild conditions, with nearly complete retention of stereochemical integrity. 1,2-DCE = 1,2-dichloroethane. © 2005 Wiley-VCH Verlag GmbH & Co, KGaA, Weinheim.

引用

页码：1378 / 1382

页数：5

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