Analysis of pharmaceutically relevant taxoids in wild yew trees from Sardinia

被引：15

作者：

Ballero, M

Loi, MC

van Rozendaal, ELM

van Beek, TA

de Haar, CV

Poli, E

Appendino, G

机构：

[1] Dipartimento Sci Bot, I-09123 Cagliari, Italy

[2] Univ Wageningen & Res Ctr, Organ Chem Lab, Phytochem Sect, NL-6703 HB Wageningen, Netherlands

[3] Dipartimento Biol Evolut, I-40126 Bologna, Italy

[4] Dipartimento Sci Chim Alimentari Farmaceut & Farm, I-28100 Novara, Italy

来源：

FITOTERAPIA | 2003年 / 74卷 / 1-2期

关键词：

Taxus baccata L; yew; diterpenoids; 10-deacetylbaccatin III; paclitaxel; Taxol (R); taxine;

D O I：

10.1016/S0367-326X(02)00301-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

Needles from a series of wild yews (Taxus baccata L.) from Sardinia were investigated for their contents of 10-deacetyl baccatin III (DAB-III, 1), paclitaxel (Taxol(R)) (2) and taxine (3). Despite a common geographical origin, ample variation of the taxoid profile was discovered, and several samples were surprisingly devoid of all terpenoid markers above. This finding is unprecedented within the European yew, while the general lack of taxine might rationalize the observation that most plants investigated are actively and impunently browsed by goats. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：34 / 39

页数：6

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