Phenotyping the haemostatic system by thrombography-potential for the estimation of thrombotic risk

被引：65

作者：

Regnault, W

Hemker, HC

Wahl, D

Lecompte, T

机构：

[1] Univ Henri Poincare, INSERM, F-54505 Vandoeuvre Les Nancy, France

[2] Univ Henri Poincare, EA 3452, F-54505 Vandoeuvre Les Nancy, France

[3] Univ Maastricht, Cardiovasc Res Inst, Maastricht, Netherlands

[4] CHU Nancy, Nancy, France

来源：

THROMBOSIS RESEARCH | 2004年 / 114卷 / 5-6期

关键词：

thrombosis; thrombin course; protein C; thrombophilia; antiphospholipid antibodies;

D O I：

10.1016/j.thromres.2004.06.017

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The aim of this paper is to review the thrombogram and its use for phenotyping the haemostatic system. The thrombogram can be readily obtained through Calibrated Automated Thrombography (CAT), using a commercially available fluorometer, dedicated software (Thrombinoscope (R)) and a calibrator. Here we explore the possibility to use platelet-rich plasma (PRP) triggered with a low amount of recombinant human tissue factor (similar to 0.5 pM) and also explore the function of the protein C system by adding activated protein C (APC) or soluble recombinant thrombomodulin (TM). Examples are shown: inherited antithrombin (AT) and protein C deficiencies, and antiphospholipid antibodies. (c) 2004 Elsevier Ltd. All rights reserved.

引用

页码：539 / 545

页数：7

共 28 条

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