Differential temporal expression of mRNAs for ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), interleukin-6 (IL-6), and their receptors (CNTFR aα, LIFR β, IL-6R α and gp130) in injured peripheral nerves

被引:85
作者
Ito, Y
Yamamoto, M
Li, M
Doyu, M
Tanaka, F
Mutch, T
Mitsuma, T
Sobue, G [1 ]
机构
[1] Nagoya Univ, Sch Med, Dept Neurol, Nagoya, Aichi 4668550, Japan
[2] Aichi Med Univ, Dept Internal Med 4, Div Neurol, Nagakute, Aichi 48011, Japan
[3] Fukui Med Coll, Dept Internal Med 2, Fukui, Japan
关键词
ciliary neurotrophic factor; interleukin-6; leukemia inhibitory factor; receptor; nerve injury; mRNA expression;
D O I
10.1016/S0006-8993(98)00242-X
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The mRNA expression of the neuropoietic cytokines, ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), interleukin-6 (IL-6), and their receptor components (CNTFR alpha, LIFR beta, IL-6R alpha and gp130) was examined in peripheral nerves after two different types of injury, crush and transection. The CNTF mRNA expression levels decreased after injury and remained low in the transected model, but recovered in 4 weeks in the crushed model. The LIF mRNA rapidly increased after damage and returned gradually to control levels. The IL-6 mRNA expression increased rapidly within 1 day after injury but dramatically decreased soon after. The CNTFR alpha mRNA levels gradually increased after nerve injury. LIFR beta was expressed in the intact nerve and decreased slightly after injury. The IL-6R alpha expression was observed faintly in the intact nerve and increased significantly soon after injury. There was also an increase in the expression of gp130. Although the temporal expression of these neuropoietic cytokines and receptors was extremely different, their pattern was similar between the crushed and transected models, except for CNTF. These results suggest that the expression of the ligands and receptors are differentially regulated after peripheral nerve injury, implying that each cytokine and signal transduction system has entirely distinctive functions in neuronal regeneration and repair. (C) 1998 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:321 / 327
页数:7
相关论文
共 38 条
[1]   MAJOR CHANGES IN THE EXPRESSION OF THE MESSENGER-RNAS FOR CHOLINERGIC DIFFERENTIATION FACTOR LEUKEMIA INHIBITORY FACTOR AND ITS RECEPTOR AFTER INJURY TO ADULT PERIPHERAL-NERVES AND GANGLIA [J].
BANNER, LR ;
PATTERSON, PH .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (15) :7109-7113
[2]   NEUROTROPHIC FACTORS AND THEIR RECEPTORS [J].
BARBACID, M .
CURRENT OPINION IN CELL BIOLOGY, 1995, 7 (02) :148-155
[3]   REGULATION OF INTERLEUKIN-6 RECEPTOR EXPRESSION IN HUMAN-MONOCYTES AND MONOCYTE-DERIVED MACROPHAGES - COMPARISON WITH THE EXPRESSION IN HUMAN HEPATOCYTES [J].
BAUER, J ;
BAUER, TM ;
KALB, T ;
TAGA, T ;
LENGYEL, G ;
HIRANO, T ;
KISHIMOTO, T ;
ACS, G ;
MAYER, L ;
GEROK, W .
JOURNAL OF EXPERIMENTAL MEDICINE, 1989, 170 (05) :1537-1549
[4]   NEUROPOIETIC CYTOKINES IN THE HEMATOPOIETIC FOLD [J].
BAZAN, JF .
NEURON, 1991, 7 (02) :197-208
[5]  
BOLIN LM, 1995, J NEUROCHEM, V64, P850
[6]   RETROGRADE AXONAL-TRANSPORT OF LIF IS INCREASED BY PERIPHERAL-NERVE INJURY - CORRELATION WITH INCREASED LIF EXPRESSION IN DISTAL NERVE [J].
CURTIS, R ;
SCHERER, SS ;
SOMOGYI, R ;
ADRYAN, KM ;
IP, NY ;
ZHU, Y ;
LINDSAY, RM ;
DISTEFANO, PS .
NEURON, 1994, 12 (01) :191-204
[7]   RETROGRADE AXONAL-TRANSPORT OF CILIARY NEUROTROPHIC FACTOR IS INCREASED BY PERIPHERAL-NERVE INJURY [J].
CURTIS, R ;
ADRYAN, KM ;
ZHU, Y ;
HARKNESS, PJ ;
LINDSAY, RM ;
DISTEFANO, PS .
NATURE, 1993, 365 (6443) :253-255
[8]   LIFR-BETA AND GP-130 AS HETERODIMERIZING SIGNAL TRANSDUCERS OF THE TRIPARTITE CNTF RECEPTOR [J].
DAVIS, S ;
ALDRICH, TH ;
STAHL, N ;
PAN, L ;
TAGA, T ;
KISHIMOTO, T ;
IP, NY ;
YANCOPOULOS, GD .
SCIENCE, 1993, 260 (5115) :1805-1808
[9]   RELEASED FORM OF CNTF RECEPTOR-ALPHA COMPONENT AS A SOLUBLE MEDIATOR OF CNTF RESPONSES [J].
DAVIS, S ;
ALDRICH, TH ;
IP, NY ;
STAHL, N ;
SCHERER, S ;
FARRUGGELLA, T ;
DISTEFANO, PS ;
CURTIS, R ;
PANAYOTATOS, N ;
GASCAN, H ;
CHEVALIER, S ;
YANCOPOULOS, GD .
SCIENCE, 1993, 259 (5102) :1736-1739
[10]   THE RECEPTOR FOR CILIARY NEUROTROPHIC FACTOR [J].
DAVIS, S ;
ALDRICH, TH ;
VALENZUELA, DM ;
WONG, V ;
FURTH, ME ;
SQUINTO, SP ;
YANCOPOULOS, GD .
SCIENCE, 1991, 253 (5015) :59-63