Pathophysiology and types of dyslipidemia in PCOS

被引:214
作者
Diamanti-Kandarakis, Evanthia
Papavassiliou, Athanasios G.
Kandarakis, Stylianos A. [1 ]
Chrousos, George P.
机构
[1] Univ Athens, Sch Med, Dept Med 1, Laiko Gen Hosp,Endocrine Sect, GR-11527 Athens, Greece
[2] Univ Athens, Sch Med, Dept Biol Chem, GR-11527 Athens, Greece
[3] Univ Athens, Dept Pediat 1, Agia Sophia Childrens Hosp, GR-11527 Athens, Greece
关键词
D O I
10.1016/j.tem.2007.07.004
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Polycystic ovary syndrome (PCOS) is an endocrinopathy that affects women of reproductive age. PCOS shares components with the metabolic syndrome and has broad health implications. Lipid abnormalities, including elevated low-density lipoprotein (LDL), triglyceride levels and decreased high-density lipoprotein (HDL), are often found in women with PCOS. It is clear that obesity, insulin resistance and hyperandrogenism coexist in PCOS, and have independent and interactive effects on dyslipidemia, although the mechanisms of these interactions remain elusive. Here, we review the types and pathophysiology of dyslipidemia associated with PCOS and its related conditions.
引用
收藏
页码:280 / 285
页数:6
相关论文
共 63 条
[1]   The regulation of HSL and LPL expression by DHT and flutamide in human subcutaneous adipose tissue [J].
Anderson, LA ;
McTernan, PG ;
Harte, AL ;
Barnett, AH ;
Kumar, S .
DIABETES OBESITY & METABOLISM, 2002, 4 (03) :209-213
[2]   Decreased atherosclerosis in heterozygous low density lipoprotein receptor-deficient mice expressing the scavenger receptor BI transgene [J].
Arai, T ;
Wang, N ;
Bezouevski, M ;
Welch, C ;
Tall, AR .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (04) :2366-2371
[3]   Regulation of microsomal triglyceride transfer protein gene by insulin in HepG2 cells -: Roles of MAPKerk and MAPKp38 [J].
Au, WS ;
Kung, HF ;
Lin, MC .
DIABETES, 2003, 52 (05) :1073-1080
[4]  
AUSTIN MA, 1988, JAMA-J AM MED ASSOC, V260, P1917
[5]   Central role of the adipocyte in the metabolic syndrome [J].
Bergman, RN ;
Van Citters, GW ;
Mittelman, SD ;
Dea, MK ;
Hamilton-Wessler, M ;
Kim, SP ;
Ellmerer, M .
JOURNAL OF INVESTIGATIVE MEDICINE, 2001, 49 (01) :119-126
[6]   Atherogenic lipoprotein phenotype and low-density lipoproteins size and subclasses in women with polycystic ovary syndrome [J].
Berneis, Kaspar ;
Rizzo, Manfredi ;
Lazzaroni, Veronica ;
Fruzzetti, Franca ;
Carmina, Enrico .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2007, 92 (01) :186-189
[7]   METABOLIC ABNORMALITIES IN VISCERAL OBESITY [J].
BJORNTORP, P .
ANNALS OF MEDICINE, 1992, 24 (01) :3-5
[8]   Difference in body weight between American and Italian women with polycystic ovary syndrome: influence of the diet [J].
Carmina, E ;
Legro, RS ;
Stamets, K ;
Lowell, J ;
Lobo, RA .
HUMAN REPRODUCTION, 2003, 18 (11) :2289-2293
[9]   RISK-FACTORS FOR CORONARY-ARTERY DISEASE IN LEAN AND OBESE WOMEN WITH THE POLYCYSTIC-OVARY-SYNDROME [J].
CONWAY, GS ;
AGRAWAL, R ;
BETTERIDGE, DJ ;
JACOBS, HS .
CLINICAL ENDOCRINOLOGY, 1992, 37 (02) :119-125
[10]  
CORDBOULD A, 2007, J ENDOCRINOL, V192, P585