Characterization of novel methyl-branched chain fatty acids from a halophilic Bacillus species

被引:28
作者
Carballeira, NM
Miranda, C
Lozano, CM
Nechev, JT
Ivanova, A
Ilieva, M
Tzvetkova, I
Stefanov, K
机构
[1] Univ Puerto Rico, Dept Chem, San Juan, PR 00931 USA
[2] Univ Turabo, Dept Sci & Technol, Gurabo, PR USA
[3] Bulgarian Acad Sci, Inst Organ Chem, Ctr Phytochem, BU-1113 Sofia, Bulgaria
[4] Bulgarian Acad Sci, Inst Microbiol, Ctr Phytochem, BU-1113 Sofia, Bulgaria
[5] Bulgarian Acad Sci, Inst Plant Physiol, Ctr Phytochem, BU-1113 Sofia, Bulgaria
来源
JOURNAL OF NATURAL PRODUCTS | 2001年 / 64卷 / 02期
关键词
D O I
10.1021/np000494d
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
The 4-methylated fatty acids 4,9-dimethyldecanoic, 4,11-dimethyldodecanoic, 4,10-dimethyldodecanoic, and 4,13-dimethyltetradecanoic acid as well as the 2-methylated fatty acids 2,13-dimethyltetradecanoic and 2, 12-dimethyltetradecanoic acid were identified for the first time in nature in the halophilic bacterium Bacillus sp. isolated from the salt pans of Burgas in Bulgaria. The principal fatty acids in this bacterium were a series of iso-anteiso fatty acids with chain lengths between C-11 and C-19, but an interesting series of linear alkylbenzene fatty acids with chain lengths between C-10 and C-14, such as 12-phenyldodecanoic acid, were also identified. The novel 4-methylated fatty acids were characterized using a combination of GC-MS and chemical transformations such as N-acylpyrrolidide derivatization. The 2-methylated fatty acids were also identified by GC-MS and gas chromatographic coelution with synthetic samples. The novel methyl-branched fatty acids probably originated from the selective incorporation of methylmalonyl-CoA by one of the fatty acid-synthesizing enzymes of the bacterium.
引用
收藏
页码:256 / 259
页数:4
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