Treatment of Childhood Kaposiform Hemangioendothelioma With Sirolimus

被引：138

作者：

Blatt, Julie ^{[1
]}

Stavas, Joseph ^{[1
]}

Moats-Staats, Billie ^{[1
]}

Woosley, John ^{[1
]}

Morrell, Dean S. ^{[1
]}

机构：

[1] Univ N Carolina, Div Pediat Hematol Oncol, Vasc Lesions Clin, Chapel Hill, NC 27599 USA

来源：

PEDIATRIC BLOOD & CANCER | 2010年 / 55卷 / 07期

关键词：

angiogenesis; new agents; vascular malformations; MALFORMATIONS IN-VIVO; RECIPIENTS; GROWTH;

D O I：

10.1002/pbc.22766

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Sirolimus (Rapamune), a mammalian target of Rapamycin (mTOR) inhibitor, which his been used extensively in children following solid organ transplantation has been demonstrated to have anti angiogenic activity in pre clinical models Limited experience suggests that it may have application to the treatment of vascular lesions We describe our experience with a 1 year old female with a kaposiform hemangioendothelioma and Kasabach-Merritt phenomenon who had rapid and dramatic response to sirolimus (0 1 mg/kg/day) This case provides further rationale for clinical trials of sirolimus in the treatment of vascular lesions Pediatr Blood Cancer 2010 55 1396-1398 (C) 2010 Wiley Liss Inc

引用

页码：1396 / 1398

页数：3

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