HLA-E-restricted recognition of cytomegalovirus-derived peptides by human CD8+ cytolytic T lymphocytes

被引：172

作者：

Pietra, G

Romagnani, C

Mazzarino, P

Falco, M

Millo, E

Moretta, A

Moretta, L

Mingari, MC

机构：

[1] Ist Giannina Gaslini, I-16147 Genoa, Italy

[2] Univ Genoa, Dipartimento Oncol Biol & Genet, I-16132 Genoa, Italy

[3] Univ Genoa, Ctr Eccellenza Ric Biomed, I-16132 Genoa, Italy

[4] Univ Genoa, Dipartimento Med Sperimentale, I-16132 Genoa, Italy

[5] Ist Nazl Ric Canc, I-16132 Genoa, Italy

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2003年 / 100卷 / 19期

关键词：

D O I：

10.1073/pnas.1834449100

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

HLA-E-restricted T cell receptor alphabeta(+) CD8(+) cytolytic T lymphocytes (CTLs) exist as monoclonal expansions in the peripheral blood of some individuals. Here, we show that they recognize, with high avidity, peptides derived from the UL40 protein of different human cytomegalovirus (CMV) strains. Recognition results in the induction of cytotoxicity, IFN-gamma production and cell proliferation. Autologous cells pulsed with CMV-derived peptides become susceptible to lysis by HLA-E-restricted CTLs and induce their proliferation. The high avidity for CMV-derived peptides may explain how these cells are generated in vivo and suggest their possible role in the host defenses against CMV, a virus that evolved various mechanisms to down-regulate classical HLA class I molecules, thus escaping detection by conventional CTLs.

引用

页码：10896 / 10901

页数：6

共 39 条

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