Inflammation and Hypertension: New Understandings and Potential Therapeutic Targets

被引：177

作者：

De Miguel, Carmen ^{[1
]}

Rudemiller, Nathan P. ^{[2
]}

Abais, Justine M. ^{[2
]}

Mattson, David L. ^{[2
]}

机构：

[1] Univ Alabama Birmingham, Dept Med, Div Nephrol, Sect Cardiorenal Physiol & Med, Birmingham, AL 35294 USA

[2] Med Coll Wisconsin, Dept Physiol, Milwaukee, WI 53226 USA

来源：

CURRENT HYPERTENSION REPORTS | 2015年 / 17卷 / 01期

关键词：

Immunity; T lymphocytes; Cytokines; Toll-like receptors; Inflammasome; REGULATORY T-CELLS; TOLL-LIKE RECEPTORS; PATTERN-RECOGNITION RECEPTORS; CHRONIC KIDNEY-DISEASE; DENDRITIC CELLS; ENDOTHELIAL DYSFUNCTION; BLOOD-PRESSURE; INNATE IMMUNITY; T(H)17 CELLS; MOLECULAR-PATTERNS;

D O I：

10.1007/s11906-014-0507-z

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Research studying the role of inflammation in hypertension and cardiovascular disease has flourished in recent years; however, the exact mechanisms by which the activated immune cells lead to the development and maintenance of hypertension remain to be elucidated. The objectives of this brief review are to summarize and discuss the most recent findings in the field, with special emphasis on potential therapeutics to treat or prevent hypertension. This review will cover novel immune cell subtypes recently associated to the disease including the novel role of cytokines, toll-like receptors, and inflammasomes in hypertension.

引用

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