Perspective on the osteoclast - An angiogenic cell?

被引：15

作者：

Cackowski, Frank C. ^{[1
,2
]}

Roodman, G. David ^{[1
,2
]}

机构：

[1] VA Pittsburg Healthcare Syst, Pittsburgh, PA 15240 USA

[2] Univ Pittsburgh, Sch Med, Pittsburgh, PA USA

来源：

SKELETAL BIOLOGY AND MEDICINE, PT B: DISEASE MECHANISMS AND THERAPEUTIC CHALLENGES | 2007年 / 1117卷

关键词：

osteoclast; angiogenesis; bone; ENDOTHELIAL GROWTH-FACTOR; COLONY-STIMULATING FACTOR; CHICK CHORIOALLANTOIC MEMBRANE; MESSENGER-RNA EXPRESSION; OSTEOBLAST-LIKE CELLS; NECROSIS-FACTOR-ALPHA; MARROW STROMAL CELLS; GORHAM-STOUT-DISEASE; HUMAN MYELOMA CELLS; NF-KAPPA-B;

D O I：

10.1196/annals.1402.073

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

There have been reports recently that the osteoclast stimulates angiogenesis in vitro. We review the evidence suggesting that the osteoclast directly stimulates angiogenesis, and discuss the feasibility of the hypothesis that the osteoclast can be a proangiogenic cell. Reasons supporting the feasibility of this hypothesis include proangiogenic factors produced by osteoclasts, the angiogenic effects of macrophages, the antiangiogenic effects of nitrogen containing bisphosphonates, and the physical proximity of osteoclasts to endothelial cells.

引用

页码：12 / 25

页数：14

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