Effects of thromboxane A2 antagonist on airway hyperresponsiveness, exhaled nitric oxide, and induced sputum eosinophils in asthmatics

被引：23

作者：

Aizawa, H ^{[1
]}

Inoue, H ^{[1
]}

Nakano, H ^{[1
]}

Matsumoto, K ^{[1
]}

Yoshida, M ^{[1
]}

Fukuyama, S ^{[1
]}

Koto, H ^{[1
]}

Hara, N ^{[1
]}

机构：

[1] Kyushu Univ, Fac Med, Chest Dis Res Inst, Higashi Ku, Fukuoka 8128582, Japan

来源：

PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS | 1998年 / 59卷 / 03期

关键词：

D O I：

10.1016/S0952-3278(98)90061-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We examined effects of a thromboxane A(2) (TXA(2)) antagonist seratrodast on airway hyperresponsiveness, exhaled nitric oxide (NO), and eosinophils in induced sputum in 14 asthmatics. Subjects were administered 80 mg of seratrodast once a day for 4 weeks. Respiratory conductance (Grs) was measured by the forced oscillation method and airway responsiveness was evaluated as the inhaled dose of methacholine, which induced 35% decrease in Grs. Subjects breathed into a Teflon bag, and NO concentration in the bag was measured by a chemiluminescence analyzer. Induced sputum comprised the entire expectorate produced during a 20 min inhalation of 3% saline, and was analyzed for total and differential cell counts. Airway hyperresponsiveness was significantly decreased by seratrodast. By contrast, no differences in either exhaled NO or percentage of eosinophils in sputum were observed before or after seratrodast. We conclude that seratrodast may attenuate airway hyperresponsiveness, presumably by antagonizing TXA(2) released from the inflamed airways.

引用

页码：185 / 190

页数：6

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