DrugBank: a knowledgebase for drugs, drug actions and drug targets

被引:2009
作者
Wishart, David S. [1 ]
Knox, Craig
Guo, An Chi
Cheng, Dean
Shrivastava, Savita
Tzur, Dan
Gautam, Bijaya
Hassanali, Murtaza
机构
[1] Univ Alberta, Dept Comp Sci, Edmonton, AB T6G 2E8, Canada
关键词
D O I
10.1093/nar/gkm958
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
DrugBank is a richly annotated resource that combines detailed drug data with comprehensive drug target and drug action information. Since its first release in 2006, DrugBank has been widely used to facilitate in silico drug target discovery, drug design, drug docking or screening, drug metabolism prediction, drug interaction prediction and general pharmaceutical education. The latest version of DrugBank (release 2.0) has been expanded significantly over the previous release. With similar to 4900 drug entries, it now contains 60 more FDA-approved small molecule and biotech drugs including 10% more experimental drugs. Significantly, more protein target data has also been added to the database, with the latest version of DrugBank containing three times as many non-redundant protein or drug target sequences as before (1565 versus 524). Each DrugCard entry now contains more than 100 data fields with half of the information being devoted to drug/chemical data and the other half devoted to pharmacological, pharmacogenomic and molecular biological data. A number of new data fields, including fooddrug interactions, drugdrug interactions and experimental ADME data have been added in response to numerous user requests. DrugBank has also significantly improved the power and simplicity of its structure query and text query searches. DrugBank is available at http://www.drugbank.ca.
引用
收藏
页码:D901 / D906
页数:6
相关论文
共 26 条
  • [1] The European Bioinformatics Institute's data resources: towards systems biology
    Brooksbank, C
    Cameron, G
    Thornton, J
    [J]. NUCLEIC ACIDS RESEARCH, 2005, 33 : D46 - D53
  • [2] Rapid identification of P-glycoprotein substrates and inhibitors
    Chang, Cheng
    Bahadduri, Praveen M.
    Polli, James E.
    Swaan, Peter W.
    Ekins, Sean
    [J]. DRUG METABOLISM AND DISPOSITION, 2006, 34 (12) : 1976 - 1984
  • [3] TTD: Therapeutic Target Database
    Chen, X
    Ji, ZL
    Chen, YZ
    [J]. NUCLEIC ACIDS RESEARCH, 2002, 30 (01) : 412 - 415
  • [4] New uses for old drugs
    Chong, Curtis R.
    Sullivan, David J., Jr.
    [J]. NATURE, 2007, 448 (7154) : 645 - 646
  • [5] The role of innovation in drug development
    Drews, J
    Ryser, S
    [J]. NATURE BIOTECHNOLOGY, 1997, 15 (13) : 1318 - 1319
  • [6] Quality of consumer drug information provided by four Web sites
    Hatfield, CL
    May, SK
    Markoff, JS
    [J]. AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY, 1999, 56 (22) : 2308 - 2311
  • [7] The PharmGKB: integration, aggregation, and annotation of pharmacogenomic data and knowledge
    Hodge, A. E.
    Altman, R. B.
    Klein, T. E.
    [J]. CLINICAL PHARMACOLOGY & THERAPEUTICS, 2007, 81 (01) : 21 - 24
  • [8] The druggable genome
    Hopkins, AL
    Groom, CR
    [J]. NATURE REVIEWS DRUG DISCOVERY, 2002, 1 (09) : 727 - 730
  • [9] Recent advances in computational prediction of drug absorption and permeability in drug discovery
    Hou, Tingjun
    Wang, Junmei
    Zhang, Wei
    Wang, Wei
    Xu, Xiaojie
    [J]. CURRENT MEDICINAL CHEMISTRY, 2006, 13 (22) : 2653 - 2667
  • [10] Analysis of genomic and proteomic data using advanced literature mining
    Hu, YH
    Hines, LM
    Weng, HF
    Zuo, DM
    Rivera, M
    Richardson, A
    LaBaer, J
    [J]. JOURNAL OF PROTEOME RESEARCH, 2003, 2 (04) : 405 - 412