Dynamic glycosylation of the transcription factor CREB: A potential role in gene regulation

被引：97

作者：

Lamarre-Vincent, N ^{[1
]}

Hsieh-Wilson, LC ^{[1
]}

机构：

[1] CALTECH, Div Chem & Chem Engn, Pasadena, CA 91125 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2003年 / 125卷 / 22期

关键词：

D O I：

10.1021/ja028200t

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We report that CREB (cyclic AMP-responsive element-binding protein), a transcription factor essential for long-term memory, is O-GlcNAc glycosylated in the mammalian brain. Glycosylation occurs at two sites within the Q2 domain and disrupts the interaction between CREB and TAFII130, thereby repressing the transcriptional activity of CREB in vitro. These findings have important implications for the role of O-GlcNAc glycosylation in gene regulation, and they provide a link between O-GlcNAc and information storage processes in the brain. Copyright © 2003 American Chemical Society.

引用

页码：6612 / 6613

页数：2

共 23 条

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