NOTCH: THE PAST, THE PRESENT, AND THE FUTURE

被引：182

作者：

Artayanis-Tsakonas, Spyros ^{[1
,2
]}

Muskavitch, Marc A. T. ^{[3
]}

机构：

[1] Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

[2] Coll France, Dept Biol & Genet Dev, F-75231 Paris, France

[3] Boston Coll, Dept Biol, Chestnut Hill, MA 02167 USA

来源：

NOTCH SIGNALING | 2010年 / 92卷

关键词：

ACUTE LYMPHOBLASTIC-LEUKEMIA; EPIDERMAL GROWTH-FACTOR; CELL FATE DECISIONS; EGF-LIKE REPEATS; DROSOPHILA-MELANOGASTER; CAENORHABDITIS-ELEGANS; C-ELEGANS; INTRACELLULAR DOMAIN; SIGNALING PATHWAY; STEM-CELLS;

D O I：

10.1016/S0070-2153(10)92001-2

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Proliferating investigations of the Notch pathway have given rise to the Notch "field," which has grown exponentially over the past 30 years. This field, founded by investigations of embryology and genetics in Drosophila, now encompasses many metazoa, including humans. The increasingly diverse scope of the field has engendered an expanding understanding that normal Notch pathway function is central to most developmental decision-making in animals, and that pathway dysfunction is implicated in many diseases, including cancer. We provide a personal view of the foundations and rapid evolution of the Notch field; and we discuss a variety of outstanding conundrums and questions regarding Notch biology, for which answers will be found and refined during the next 30 years.

引用

页码：1 / 29

页数：29

共 124 条

[1]

[Anonymous], 1950, Biology of Drosophila

[2]

[Anonymous], PLAUSIBILITY LIFE GR

[3] CSL-independent Notch signalling: a checkpoint in cell fate decisions during development? [J].

Arias, AM ;

Zecchini, V ;

Brennan, K .

CURRENT OPINION IN GENETICS & DEVELOPMENT, 2002, 12 (05) :524-533

[4] Notch signaling: Cell fate control and signal integration in development [J].

Artavanis-Tsakonas, S ;

Rand, MD ;

Lake, RJ .

SCIENCE, 1999, 284 (5415) :770-776

[5] MOLECULAR-CLONING OF NOTCH, A LOCUS AFFECTING NEUROGENESIS IN DROSOPHILA-MELANOGASTER [J].

ARTAVANISTSAKONAS, S ;

MUSKAVITCH, MAT ;

YEDVOBNICK, B .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (07) :1977-1981

[6] THE MOLECULAR-BIOLOGY OF THE NOTCH LOCUS AND THE FINE TUNING OF DIFFERENTIATION IN DROSOPHILA [J].

ARTAVANISTSAKONAS, S .

TRENDS IN GENETICS, 1988, 4 (04) :95-100

[7] Characterization of Notch1 Antibodies That Inhibit Signaling of Both Normal and Mutated Notch1 Receptors [J].

Aste-Amezaga, Miguel ;

Zhang, Ningyan ;

Lineberger, Janet E. ;

Arnold, Beth A. ;

Toner, Timothy J. ;

Gu, Mingcheng ;

Huang, Lingyi ;

Vitelli, Salvatore ;

Vo, Kim T. ;

Haytko, Peter ;

Zhao, Jing Zhang ;

Baleydier, Frederic ;

L'Heureux, Sarah ;

Wang, Hongfang ;

Gordon, Wendy R. ;

Thoryk, Elizabeth ;

Andrawes, Marie Blanke ;

Tiyanont, Kittichoat ;

Stegmaier, Kimberly ;

Roti, Giovanni ;

Ross, Kenneth N. ;

Franlin, Laura L. ;

Wang, Hui ;

Wang, Fubao ;

Chastain, Michael ;

Bett, Andrew J. ;

Audoly, Laurent P. ;

Aster, Jon C. ;

Blacklow, Stephen C. ;

Huber, Hans E. .

PLOS ONE, 2010, 5 (02)

[8] GLP-1 IS REQUIRED IN THE GERM LINE FOR REGULATION OF THE DECISION BETWEEN MITOSIS AND MEIOSIS IN C-ELEGANS [J].

AUSTIN, J ;

KIMBLE, J .

CELL, 1987, 51 (04) :589-599

[9] An overview of the Notch signalling pathway [J].

Baron, M .

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 2003, 14 (02) :113-119

[10]

Beatus P, 1999, DEVELOPMENT, V126, P3925

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