Metabolites: a helping hand for pathway evolution?

被引:98
作者
Schmidt, S
Sunyaev, S
Bork, P
Dandekar, T
机构
[1] European Mol Biol Lab, D-69012 Heidelberg, Germany
[2] Univ Heidelberg, Dept Parasitol, D-69120 Heidelberg, Germany
[3] Univ Wurzburg, Biozentrum, Dept Bioinformat, D-97074 Wurzburg, Germany
[4] Max Delbruck Ctr Mol Med, D-13122 Berlin, Germany
关键词
D O I
10.1016/S0968-0004(03)00114-2
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The evolution of enzymes and pathways is under debate. Recent studies show that recruitment of single enzymes from different pathways could be the driving force for pathway evolution. Other mechanisms of evolution, such as pathway duplication, enzyme specialization, de novo invention of pathways or retro-evolution of pathways, appear to be less abundant. Twenty percent of enzyme superfamilies are quite variable, not only in changing reaction chemistry or metabolite type but in changing both at the same time. These variable superfamilies account for nearly half of all known reactions. The most frequently occurring metabolites provide a helping hand for such changes because they can be accommodated by many enzyme superfamilies. Thus, a picture is emerging in which new pathways are evolving from central metabolites by preference, thereby keeping the overall topology of the metabolic network.
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页码:336 / 341
页数:6
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