Multimodality multidimensional image analysis of cortical and subcortical plasticity in the rat brain

被引:5
作者
Goldszal, AF
Tretiak, OJ
Liu, DD
Hand, PJ
机构
[1] DREXEL UNIV, IMAGING & COMP VIS CTR, PHILADELPHIA, PA 19104 USA
[2] UNIV PENN, MAHONEY INST NEUROL SCI, PHILADELPHIA, PA 19104 USA
[3] UNIV PENN, SCH VET MED, DEPT ANIM BIOL, PHILADELPHIA, PA 19104 USA
关键词
multimodality imaging; image registration; brain mapping; brain plasticity; rat brain; imaging;
D O I
10.1007/BF02660892
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
In this work, we developed and implemented a multimodality multidimensional imaging system which is capable of generating and displaying anatomical and functional images of selected structures and processes within a vertebrate's central nervous system (CNS). The functional images an generated from [C-14]-2-deoxy-D-glucose (2DG) autoradiography whereas the anatomic images are derived from cytochrome oxidase (GO) histochemistry. This multi-modality imaging system has been used to study mechanisms underlying information processing in the rat brain. We have applied this technique to visualize and measure the plasticity (deformation) observed in the rat's whisker system due to neonatal lesioning of selected peripheral sensory organs. Application of this imaging system revealed detailed information about the shape, size, and directionality of selected cortical and subcortical structures. Previous 2-D imaging techniques were unable to deliver such holistic information. Another important issue addressed in this work is related to image registration problems. We developed an image registration technique which employs extrinsic fiduciary marks for alignment and is capable of registering images with subpixel accuracy. It uses the information from all available fiduciary marks to promote alignment of the sections and to avoid propagation of errors across a serial data set.
引用
收藏
页码:430 / 439
页数:10
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