The role of the oral environment in HIV-1 transmission

被引：71

作者：

Shugars, DC

Wahl, SM

机构：

[1] Univ N Carolina, Sch Dent, Dept Dent Ecol, Chapel Hill, NC 27599 USA

[2] Univ N Carolina, Sch Med, Dept Immunol & Microbiol, Chapel Hill, NC 27599 USA

[3] NIDR, Oral Infect & Immun Branch, NIH, Bethesda, MD 20892 USA

来源：

JOURNAL OF THE AMERICAN DENTAL ASSOCIATION | 1998年 / 129卷 / 07期

关键词：

D O I：

10.14219/jada.archive.1998.0349

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

Human immunodeficiency virus type 1, or HIV-1, is infrequently transmitted through the mouth, unlike other mucosal sites. Factors such as low salivary viral titers, low numbers of CD4-positive target cells, anti-HIV antibodies and endogenous salivary antiviral factors work in concert to protect oral tissues from Infection and reduce the risk of viral transmission through salivary secretions. This review summarizes the various factors thought to influence oral transmission of HIV-1, focusing on the mucosal protein secretory leukocyte protease inhibitor, or SLPI.

引用

收藏

页码：851 / 858

页数：8

相关论文

共 84 条

[1] PRODUCTIVE, PERSISTENT INFECTION OF HUMAN COLORECTAL CELL-LINES WITH HUMAN-IMMUNODEFICIENCY-VIRUS [J].

ADACHI, A ;

KOENIG, S ;

GENDELMAN, HE ;

DAUGHERTY, D ;

GATTONICELLI, S ;

FAUCI, AS ;

MARTIN, MA .

JOURNAL OF VIROLOGY, 1987, 61 (01) :209-213

[2] CC CKRS: A RANTES, MIP-1 alpha, MIP-1 beta receptor as a fusion cofactor for macrophage-tropic HIV-1 [J].

Alkhatib, G ;

Combadiere, C ;

Broder, CC ;

Feng, Y ;

Kennedy, PE ;

Murphy, PM ;

Berger, EA .

SCIENCE, 1996, 272 (5270) :1955-1958

[3]

[Anonymous], 1987, Lancet, V2, P522

[4] INVITRO INHIBITION OF HIV-1 INFECTIVITY BY HUMAN SALIVAS [J].

ARCHIBALD, DW ;

COLE, GA .

AIDS RESEARCH AND HUMAN RETROVIRUSES, 1990, 6 (12) :1425-1432

[5]

ARCHIBALD DW, 1986, BLOOD, V67, P831

[6] Mucosal immune responses in four distinct compartments of women infected with human immunodeficiency virus type 1: A comparison by site and correlation with clinical information [J].

Artenstein, AW ;

VanCott, TC ;

Sitz, KV ;

Robb, ML ;

Wagner, KF ;

Veit, SCD ;

Rogers, AF ;

Garner, RP ;

Byron, JW ;

Burnett, PR ;

Birx, DL .

JOURNAL OF INFECTIOUS DISEASES, 1997, 175 (02) :265-271

[7] ACUTELY INFECTED LANGERHANS CELLS ARE MORE EFFICIENT THAN T-CELLS IN DISSEMINATING HIV TYPE-1 TO ACTIVATED T-CELLS FOLLOWING A SHORT CELL-CELL CONTACT [J].

AYEHUNIE, S ;

GROVES, RW ;

BRUZZESE, AM ;

RUPRECHT, RM ;

KUPPER, TS ;

LANGHOFF, E .

AIDS RESEARCH AND HUMAN RETROVIRUSES, 1995, 11 (08) :877-884

[8] MUCOSAL INFECTION OF NEONATAL RHESUS-MONKEYS WITH CELL-FREE SIV [J].

BABA, TW ;

KOCH, J ;

MITTLER, ES ;

GREENE, M ;

WYAND, M ;

PENNINCK, D ;

RUPRECHT, RM .

AIDS RESEARCH AND HUMAN RETROVIRUSES, 1994, 10 (04) :351-357

[9] Infection and AIDS in adult macaques after nontraumatic oral exposure to cell-free SIV [J].

Baba, TW ;

Trichel, AM ;

An, L ;

Liska, V ;

Martin, LN ;

MurpheyCorb, M ;

Ruprecht, RM .

SCIENCE, 1996, 272 (5267) :1486-1489

[10]

BARR CE, 1992, J AM DENT ASSOC, V123, P37

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