The renal excretory mechanisms and the role of organic cations in modulating the renal handling of paraquat

被引：27

作者：

Chan, BSH

Lazzaro, VA

Seale, JP

Duggin, GG

机构：

[1] Royal Prince Alfred Hosp, Dept Renal Med, Camperdown, NSW 2050, Australia

[2] Royal Prince Alfred Hosp, Toxicol Unit, Camperdown, NSW 2050, Australia

[3] Univ Sydney, Dept Pharmacol, Sydney, NSW 2006, Australia

来源：

PHARMACOLOGY & THERAPEUTICS | 1998年 / 79卷 / 03期

关键词：

paraquat; LLC-PK1; MDCK; primary cultured rat proximal tubular cells; transport; renal excretion;

D O I：

10.1016/S0163-7258(98)00015-1

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Paraquat (PQ), a cationic herbicide, is predominantly excreted by the kidneys, but it is also nephrotoxic. It is thought to cause damage to proximal renal epithelial cells, which results in acute renal failure. The precise mechanism by which PR is excreted by the kidney has not been fully elucidated, although current evidence indicates that it is actively secreted via a cation transport system. This review examines the renal cytotoxic effect and excretory mechanisms of PQ, and the role of organic cations in modulating the renal handling of PQ. (C) 1998 Elsevier Science Inc.

引用

页码：193 / 203

页数：11

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