A novel aspect of calpain activation

被引：142

作者：

Suzuki, K ^{[1
]}

Sorimachi, H ^{[1
]}

机构：

[1] Univ Tokyo, Inst Mol & Cellular Biosci, Bunkyo Ku, Tokyo 1130032, Japan

来源：

FEBS LETTERS | 1998年 / 433卷 / 1-2期

关键词：

calpain; protease; proteolysis; activation of calpain; Ca2+; biomodulator;

D O I：

10.1016/S0014-5793(98)00856-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Calpain, a Ca2+-dependent biomodulator, alters the properties of substrate proteins by cleaving them at a limited number of specific sites. Recent studies of the structure-function relationship of calpain and X-ray analysis of its Ca2+-binding domain have revealed hitherto unknown features of the regulation of calpain activity. A novel dissociation/autolysis mechanism for the activation of calpain at the membrane is proposed, which incorporates recent findings from structure-function studies of calpain, and its implications are discussed. (C) 1998 Federation of European Biochemical Societies.

引用

页码：1 / 4

页数：4

共 33 条

[1] Autolysis parallels activation of mu-calpain [J].

Baki, A ;

Tompa, P ;

Alexa, A ;

Molnar, O ;

Friedrich, P .

BIOCHEMICAL JOURNAL, 1996, 318 :897-901

[2]

BALCHARD H, 1997, NAT STRUCT BIOL, V4, P532

[3] The calpain hypothesis of neurodegeneration: Evidence for a common cytotoxic pathway [J].

Bartus, RT .

NEUROSCIENTIST, 1997, 3 (05) :314-327

[4] CALCIUM-ACTIVATED NEUTRAL PROTEASE (CALPAIN) SYSTEM - STRUCTURE, FUNCTION, AND REGULATION [J].

CROALL, DE ;

DEMARTINO, GN .

PHYSIOLOGICAL REVIEWS, 1991, 71 (03) :813-847

[5] The effects of truncations of the small subunit on m-calpain activity and heterodimer formation [J].

Elce, JS ;

Davies, PL ;

Hegadorn, C ;

Maurice, DH ;

Arthur, JSC .

BIOCHEMICAL JOURNAL, 1997, 326 :31-38

[6]

Elce JS, 1997, J BIOL CHEM, V272, P11268

[7] IS CALPAIN ACTIVITY REGULATED BY MEMBRANES AND AUTOLYSIS OR BY CALCIUM AND CALPASTATIN [J].

GOLL, DE ;

THOMPSON, VF ;

TAYLOR, RG ;

ZALEWSKA, T .

BIOESSAYS, 1992, 14 (08) :549-556

[8] THE COOH-TERMINAL E-F HAND STRUCTURE OF CALCIUM-ACTIVATED NEUTRAL PROTEASE (CANP) IS IMPORTANT FOR THE ASSOCIATION OF SUBUNITS AND RESULTING PROTEOLYTIC ACTIVITY [J].

IMAJOH, S ;

KAWASAKI, H ;

SUZUKI, K .

JOURNAL OF BIOCHEMISTRY, 1987, 101 (02) :447-452

[9] Calpains: intact and active? [J].

Johnson, GVW ;

Guttmann, RP .

BIOESSAYS, 1997, 19 (11) :1011-1018

[10] Regulation of the calpain-calpastatin system by membranes (review) [J].

Kawasaki, H ;

Kawashima, S .

MOLECULAR MEMBRANE BIOLOGY, 1996, 13 (04) :217-224

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