Signaling by members of the TGF-β family in vascular morphogenesis and disease

被引：350

作者：

Pardali, Evangelia

Goumans, Marie-Jose

ten Dijke, Peter ^{[1
]}

机构：

[1] Leiden Univ, Med Ctr, Dept Mol Cell Biol, NL-2300 RA Leiden, Netherlands

来源：

TRENDS IN CELL BIOLOGY | 2010年 / 20卷 / 09期

关键词：

GROWTH-FACTOR-BETA; HEREDITARY HEMORRHAGIC TELANGIECTASIA; RECEPTOR-LIKE KINASE-1; BLOOD-VESSEL FORMATION; YOLK-SAC VASCULATURE; SMOOTH-MUSCLE-CELLS; ENDOTHELIAL-CELLS; PROTEIN BMP; TRANSFORMING GROWTH-FACTOR-BETA-1; SMAD1/5; PHOSPHORYLATION;

D O I：

10.1016/j.tcb.2010.06.006

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Members of the transforming growth factor-beta (TGF-beta) family play pivotal roles in development and disease. These cytokines elicit their pleiotropic effects on cells, including endothelial and mural cells, through specific type I and type II serine/threonine kinase receptors and intracellular Smad transcription factors. This review highlights recent progress in our understanding of TGF-beta signaling in vascular development and angiogenesis and of how perturbed TGF-beta signaling might contribute to vascular pathologies, tumor angiogenesis and tumor progression. Recent research has provided exciting insights into the role of the TGF-beta type I receptor (ALK1) in tumor angiogenesis and the curative effects of thalidomide on vascular malformations in hereditary hemorrhagic telangiectasia (HHT). These advances provide opportunities for the development of new therapies for diseases with vascular abnormalities.

引用

页码：556 / 567

页数：12

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